# Obstetrical and Oncological Outcomes Among Reproductive Age Women with Gynecological and Breast Cancer

> **NIH NIH K08** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $250,577

## Abstract

Project Summary
Fertility is very important to many young women diagnosed with cancer. Surgery, chemotherapy, and
radiotherapy can impact fertility and pregnancy outcomes. Conversely, pregnancy at the time of cancer
diagnosis or after cancer treatment can impact survival. Despite the increasing number of young women with
gynecological or breast cancer and the importance of accurate information in guiding counseling, evidence
regarding the impact of pregnancy or assisted reproductive technologies (ART) on oncological and obstetrical
outcomes following cancer treatment remains limited. To address these knowledge gaps, Dr. Rauh-Hain plans
to conduct a population-based observational study to estimate fertility, obstetrical, and oncological outcomes in
women age 18–45 years who are diagnosed with early-stage ovarian, uterine, cervical, or breast cancer and
opt for fertility-sparing oncologic treatment. We propose a novel linkage of four unique data sources: 1)
California Cancer Registry (CCR) data, which include information about tumor characteristics, primary cancer-
directed therapy, and survival for all cancer cases diagnosed in California; 2) California Office of Statewide
Health Planning and Development (OSHPD) Birth Data, which include maternal antepartum and postpartum
hospital records for the 9 months prior to and 1 year after delivery; 3) California OSHPD inpatient and
ambulatory surgery discharge data sets, which contain patient treatment data for all inpatient and ambulatory
surgeries; and 4) the Centers for Disease Control and Prevention (CDC) National Assisted Reproductive
Technologies (ART) Surveillance System data set, which includes all ART cycles initiated in U.S. fertility
clinics. We will supplement these data with a cross-sectional survey to identify barriers preventing
reproductive-age women from achieving successful pregnancies. This study will provide information about
oncological, fertility, and obstetrical outcomes among women who become pregnant or underwent ART after a
gynecological or breast cancer diagnosis and identify barriers that prevent reproductive-age women from
achieving successful pregnancies leading to a live birth.
Dr. Rauh-Hain is a gynecologic oncologist and health services researcher at The University of Texas MD
Anderson Cancer Center. He has a particular interest in understanding the quality of care for reproductive-age
women with cancer. His long-term career goal is to become an innovative and independently funded health
services and comparative effectiveness researcher in gynecological cancer. The research program described
here is designed to complement a career development plan that includes training in advanced statistical
modeling and survey design and implementation. This award will lay the foundation for two follow-up studies:
1) a prospective multicenter cohort study to assess barriers to, and decision-making regarding, future
pregnancies in this population and 2) the use of the linked databases to...

## Key facts

- **NIH application ID:** 9991618
- **Project number:** 5K08CA234333-03
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Jose Alejandro Rauh-Hain
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $250,577
- **Award type:** 5
- **Project period:** 2018-09-18 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9991618

## Citation

> US National Institutes of Health, RePORTER application 9991618, Obstetrical and Oncological Outcomes Among Reproductive Age Women with Gynecological and Breast Cancer (5K08CA234333-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9991618. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*