# Core-002: Biomechanics, Biomaterials and Multimodal Tissue Imaging Core (BBMTI Core)

> **NIH NIH P30** · UNIVERSITY OF ROCHESTER · 2020 · $241,041

## Abstract

Abstract: We propose the Biomechanics, Biomaterials, and Multimodal Imaging (BBMTI) Core of the 
University of Rochester Resource-Based Center for Musculoskeletal Biology and Medicine (URRBCMBM) to 
foster the multidisciplinary, synergistic research programs that have characterized the Center for 
Musculoskeletal Research (CMSR) since its creation in 2000. The CMSR's investigators work in a 
programmatic manner to address translational questions in the musculoskeletal sciences, from genetic 
pathways responsible for skeletal development and pathology, to medical problems associated with complex 
fractures, joint diseases, and tissue engineering/regenerative medicine. This highly integrated approach has 
been historically leveraged by extensive CMSR resources and institutional support, which led to significant 
funding success and national recognition. As research in the CMSR has markedly advanced, now requiring 
increased utilization of imaging and biomechanical testing in many small and large animal models of 
orthopaedic injury and repair and human cadaver tissues, and increased innovations in biomaterials for cell 
and drug delivery in these models, there is compelling rationale for reorganization and integration of our 
imaging and biomechanical testing resources with new biomaterials technologies that facilitate translation from 
bench-to-bedside. Therefore, we propose to organize the BBMTI Core into three sub-cores: 1) Biomechanical 
Testing Sub-Core, 2) Biomaterials Synthesis and Fabrication Sub-Core, and 3) Tissue and Small Animal 
Multimodal Imaging Sub-Core. The centralization of the highly specialized technologies, tools, and expertise in 
the proposed sub-cores is designed to ensure quality control and efficiency through 5 Specific Aims. Aim 1: To 
support state-of-the-art services in biomechanical testing of biomaterials and musculoskeletal tissues from 
small and large animal models of orthopaedic trauma and disease. Aim 2: To facilitate highly clinically relevant 
research activities by surgeons investigating novel implants and procedures in a brand new state-of-the-art 
Human and Large Animal Biomechanics Lab funded with significant institutional support for this program. Aim 
3. To Integrate innovations in biomaterials (nanoparticles, hydrogels, and 3D printing) for drug, siRNA, and cell 
delivery in our models of musculoskeletal repair; and provide polymer and peptide synthesis services to 
facilitate exploring alternatives to drugs and growth factors in musculoskeletal applications. 4) To provide state- 
of-the-art services in tissue and longitudinal in vivo imaging in small and large models of musculoskeletal 
trauma and disease using micro-CT, multispectral (fluorescence and bioluminescence) IVIS, and ultrasound 
imaging; and explore innovations in imaging protocols and image processing algorithms to derive translatable, 
minimally-invasive correlates of functional healing. 5) To offer cost-effective access for New Investigat...

## Key facts

- **NIH application ID:** 9991750
- **Project number:** 5P30AR069655-05
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **Principal Investigator:** Hani A Awad
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $241,041
- **Award type:** 5
- **Project period:** — → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9991750

## Citation

> US National Institutes of Health, RePORTER application 9991750, Core-002: Biomechanics, Biomaterials and Multimodal Tissue Imaging Core (BBMTI Core) (5P30AR069655-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9991750. Licensed CC0.

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