# Function Annotation Core

> **NIH NIH P01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $222,559

## Abstract

Abstract 
The ultimate goal of the Program is to develop methodologies to study cancer. One 
important aspect of it is to understand the biology, or function, underlying the large 
amount of data that will be analyzed. The four projects in this Program will deal with data 
and annotations at different levels. For example, genetic variation data will be analyzed 
in Project 1, gene and protein data is used in Project 2, 3 and 4, while microbiome and 
metabolites data is used in Project 3. Functional annotations to these datasets will be 
crucial for each project to properly analyze the data and interpret the results. The key 
focus of Core B is to support these projects by providing resources to annotate the data. 
The Core will work very closely with Core D (Data analysis and software development), 
which provides support in centralized data storage. 
The project will leverage the existing in-house annotation tools, for example, ANNOVAR 
for genetic variant annotation and PANTHER for gene/protein annotation, and identify 
external resources, prioritize and build an integrative and comprehensive infrastructure 
for annotation. The system will allow us to annotate and re-annotate data that are 
brought into the Program by Core D. It is crucial to maintain all annotations up to date, 
so it should make frequently updates from the source. It should also have a user-friendly 
interface to allow members in the Program to annotate the data while they are 
generating them, browse and identify the data of interest and retrieve shared results by 
other researchers.

## Key facts

- **NIH application ID:** 9991767
- **Project number:** 5P01CA196569-05
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Huaiyu Mi
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $222,559
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9991767

## Citation

> US National Institutes of Health, RePORTER application 9991767, Function Annotation Core (5P01CA196569-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9991767. Licensed CC0.

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