# JHU NIMH Center for Novel Therapeutics for HIV-associated Cognitive Disorders

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2020 · $1,460,217

## Abstract

PROJECT SUMMARY – OVERALL
HIV-associated neurocognitive disorders (HAND) remain very prevalent, even among aviremic HIV+ individuals
treated with CART. In the era of CART, the prevalence of HAND in HIV+ individuals with advanced infection
remains around 40-50% [1, 2], and HAND may now be the most common form of young-age neurocognitive
impairment globally [1]. Currently there are no uniformly accepted clinical, neuroimaging, or laboratory outcome
measures for clinical trials for the treatment of HAND. HIV-related neuroscience research at Johns Hopkins
University has focused on this challenging problem, exploring critical pathogenic mechanisms for neurological
damage. Despite tremendous efforts to understand the mechanisms underlying the persistence of HAND, no
definitive adjunctive therapeutics have yet entered clinical practice. There is also an unfilled need to develop
surrogate markers and more robust and simpler screening instruments for HAND, to allow for earlier detection,
for tracking of the course of HAND, and improving the efficiency of clinical trials. Until the NIMH Center was
established at JHU collaborations had been limited by the lack of a central organizing structure for this type of
research, and limited resources to facilitate cross-disciplinary and translational research. The JHU NIMH Center
has addressed these needs over the past 11 years and has provided a resource to catalyze interdisciplinary
research in HIV neuroscience, with the aim of leading to new therapies. Accomplishments of the Center are
highlighted in the Overall Strategy section and in each individual core, and the key accomplishment is our
proven ability to move HAND therapeutics from the discovery phase, through animal models, and on to
clinical trials, with the ultimate goal of shifting clinical practice.

## Key facts

- **NIH application ID:** 9991910
- **Project number:** 5P30MH075673-14
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Norman J Haughey
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,460,217
- **Award type:** 5
- **Project period:** 2006-04-01 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9991910

## Citation

> US National Institutes of Health, RePORTER application 9991910, JHU NIMH Center for Novel Therapeutics for HIV-associated Cognitive Disorders (5P30MH075673-14). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9991910. Licensed CC0.

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