# Clinical Core

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2020 · $339,101

## Abstract

PROJECT SUMMARY - CLINICAL CORE
The prevalence of HAND in HIV+ individuals with advanced infection remains around 40-50%, and HAND may
now be the most common form of young-age neurocognitive impairment globally. Currently there are no
uniformly accepted clinical, neuroimaging, or laboratory outcome measures for clinical trials for the treatment of
HAND. This Core provides the support necessary to evaluate new outcome measures of CNS function including
both neurocognitive assessments (e.g., screening tests for HAND) and performance based functional
assessments. In addition, the Core will provide well-characterized individuals for developmental projects such
as novel neuroimaging outcomes which may be more sensitive to CNS dysfunction and response to treatment
than neuropsychological test measures. The Clinical Core will also provide well-characterized individuals for
evaluating novel laboratory markers identified in the Biomarker Core. Specifically, we will examine markers of
cell stress, neuronal injury, and energy metabolism, which are also being used as platforms for therapeutic
targets in our Therapeutic Core. The goals and objectives of this Core are as follows: 1) To maintain a clinical
cohort of well-characterized HIV+ and demographically-matched HIV- individuals to improve the efficiency of
accruing and conducting clinical trials, 2) To liaise with other NIMH Centers, other funded IPCPs, the AIDS
Clinical Trials Group (ACTG), the Johns Hopkins University Center for AIDS Research (JHU CFAR), Institute for
Clinical and Translational Research (ICTR), and the Johns Hopkins University (JHU) Drug Discovery unit to
assist in the development of interventional therapeutics for HAND, 3) To provide the infrastructure and resources
necessary to conduct small early phase studies to evaluate therapeutics for HAND including novel drugs,
neuromodulation and behavioral strategies, 4) To maintain a data infrastructure to allow for efficient querying of
clinical and laboratory data, 5) To provide statistical support for all studies involving the Center Grant resources.

## Key facts

- **NIH application ID:** 9991916
- **Project number:** 5P30MH075673-14
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** NED C SACKTOR
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $339,101
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9991916

## Citation

> US National Institutes of Health, RePORTER application 9991916, Clinical Core (5P30MH075673-14). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9991916. Licensed CC0.

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