# Human Asthma Clinical Core B

> **NIH NIH U19** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $406,150

## Abstract

The “Human Asthma Clinical Core B” will be a resource to provide well characterized human lung, lung 
lymph node, sputum, and peripheral blood specimens from asthma and control subjects to allow individual 
projects to investigate whether the immune, inflammatory, and remodeling pathway they are studying is more 
highly expressed in asthma compared to control subjects, is more highly expressed in severe asthma 
compared to mild asthma, is more highly expressed in asthmatics with severe remodeling compared to mild 
remodeling, is expressed at levels that differ in different lung anatomical compartments (i.e. proximal airway 
vs distal airway vs lung lymph nodes), and whether differences in expression levels are detectable in 
peripheral blood or sputum to potentially use as a biomarker of remodeling. The Core B resources will be 
used equally in each of the three projects comprising this UCSD AADCRC (Broide, Project 1; Croft, Project 
2; Doherty, Project 3). Core B will also be a resource to provide well characterized human asthma and 
control lung cells (ILC2, CD4, smooth muscle, fibroblast, epithelium) for study in each Project. Finally, Core B 
will allow investigators in each project to utilize a novel ex vivo human lung bronchodilation, 
bronchoconstriction assay to determine whether the pathway they are studying influences bronchodilation, 
bronchoconstriction, or airway remodeling in human lungs from asthma compared to controls. Overall, the 
provision of these human lung, lung lymph node, sputum, and peripheral blood specimens from asthma and 
control subjects will allow the individual projects to determine whether the defined inflammatory and 
remodeling pathways they are investigating are different in asthmatics with differing levels of severity, 
differing levels of remodeling, or as compared to control subjects.

## Key facts

- **NIH application ID:** 9993180
- **Project number:** 5U19AI070535-15
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** DAVID H BROIDE
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $406,150
- **Award type:** 5
- **Project period:** 2006-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993180

## Citation

> US National Institutes of Health, RePORTER application 9993180, Human Asthma Clinical Core B (5U19AI070535-15). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9993180. Licensed CC0.

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