# Airway inflammation and airway remodeling - Project 1

> **NIH NIH U19** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $309,998

## Abstract

The focus of this proposal is on ORMDL-3, a protein localized to chromosome 17q21, which has been highly
linked to asthma in several genome wide association studies. The aim of this project is on understanding
how ORMDL3 expressed in bronchial smooth muscle cells influences smooth muscle contraction through
activation of SERCA2b. The study will utilize human lung smooth muscle cells in vitro, human lung sections
of asthmatics ex vivo, and in vivo studies examining mice expressing the human ORMDL3 transgene in
smooth muscle to determine how ORMDL3 activates SERCA2b to regulate smooth muscle phenotypic
changes and contraction in vitro, and influences levels of smooth muscle and airway hyperreactivity in vivo.
Overall, these studies will provide important insight into how ORMDL3, a gene highly linked to asthma,
contributes to smooth muscle remodeling and asthma.

## Key facts

- **NIH application ID:** 9993181
- **Project number:** 5U19AI070535-15
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** DAVID H BROIDE
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $309,998
- **Award type:** 5
- **Project period:** 2006-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993181

## Citation

> US National Institutes of Health, RePORTER application 9993181, Airway inflammation and airway remodeling - Project 1 (5U19AI070535-15). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9993181. Licensed CC0.

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