# Efficacy of combination therapy in the Cynomolgus macaque model

> **NIH NIH P01** · UNIVERSITY OF FLORIDA · 2020 · $776,152

## Abstract

Abstract 
Tuberculosis remains a major threat worldwide, with significant morbidity and mortality. Although drug 
treatment is available, the regimen is lengthy with drugs that can have toxicity. The emergence of drug 
resistant strains of Mycobacterium tuberculosis leads to treatment with suboptimal second line therapy. New 
strategies are necessary for effectively combating tuberculosis. 
This project is the culmination of the other projects and cores in the Program Project, in that drug regimens 
identified and tested in smaller animal models and optimized by mathematical modeling will be tested for 
efficacy in a large animal model. The cynomolgus macaque model is arguably the closest to humans in terms 
of M. tuberculosis infection outcome, pathology and disease presentation. Our previous work demonstrated the 
utility of this model in testing drugs against tuberculosis, with similar outcomes in humans and macaques. We 
combine detailed necropsy and bacterial burden determinations with advanced serial imaging using Positron 
Emission Tomography and Computed Tomography (PET/CT) to identify successful regimens. Here we will 
compare two combinations identified, tested and optimized in the other projects and cores, for efficacy against 
TB in macaques. These combination regimens will be compared separately and sequentially, providing 
preclinical data that can be used to choose the best regimen to take into human clinical trials.

## Key facts

- **NIH application ID:** 9993198
- **Project number:** 5P01AI123036-05
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** JoAnne L. Flynn
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $776,152
- **Award type:** 5
- **Project period:** 2016-08-20 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993198

## Citation

> US National Institutes of Health, RePORTER application 9993198, Efficacy of combination therapy in the Cynomolgus macaque model (5P01AI123036-05). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9993198. Licensed CC0.

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