# Future Directions: Latency and Immune Receptors

> **NIH NIH P50** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $311,488

## Abstract

ABSTRACT
The success of antiretroviral therapy (ART) has transformed the HIV/AIDS pandemic into a life-long chronic
disease, yet major challenges remain as a growing population of ~35 million patients living with HIV continues
to face significant health challenges. These include side-effects and toxicity of ART, immune dysfunction and
chronic inflammation that results in diseases associated with accelerated aging, and an increase in non-AIDS
defining cancers. Continued infections also heighten the risk of multidrug resistance. Thus, the search for a
sterilizing or functional cure that permits years of drug-free life for infected individuals has moved to center
stage for HIV/AIDS research.. We now propose to contribute to the basic science that underlies these issues
by: 1) Use hu-mice to determine the pathway of viral reactivation from latency at the anatomical and cellular
levels, 2) Determine molecular mechanisms that are important for the establishment, maintenance, and
reversal of latency, and 3) Decipher molecular mechanisms that mediate immune responses, with a focus on
receptors that localize antibodies, regulate innate immunity, and localize or regulate T-cells. These studies will
advance understanding of the latent reservoir, HIV gene expression, immune responses, and will inform the
development of eradication strategies.

## Key facts

- **NIH application ID:** 9993259
- **Project number:** 5P50AI150464-14
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** CHRISTOPHER P. HILL
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $311,488
- **Award type:** 5
- **Project period:** 2007-08-27 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993259

## Citation

> US National Institutes of Health, RePORTER application 9993259, Future Directions: Latency and Immune Receptors (5P50AI150464-14). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9993259. Licensed CC0.

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