# Core 5 - Virology, Cell, Molecular & Chemical Biology Core

> **NIH NIH U54** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $552,761

## Abstract

Core 5: Virology, Cell, Molecular and Chemical Biology Core
Summary
CRNA investigators have a wide range of expertise virology, cell and molecular biology, as well as
chemical structural biology. Each of the biologically focused projects requires the application of
techniques and expertise in these areas. To facilitate the identification of new targets for structural
and biophysical analysis, and to facilitate the validation and biological interpretation of structural and
biophysical data, the Virology, Cell, Molecular and Chemical Biology Core will undertake a number of
activities including: (1) the discovery of new RNA targets for structure function studies using CLIP (2)
the determination of RNA secondary structures in cells using DMS-MaPseq (3) siRNA and
sCAS9/SAM screening to identify and validate new protein targets for structure function studies (4)
the provision of virology and general molecular biology support to biologically and structurally focused
projects and aims (5) virtual screening and chemical synthesis to enable the discovery of RNA-
targeted inhibitors of the biological processes studied in the CRNA.

## Key facts

- **NIH application ID:** 9993265
- **Project number:** 5U54AI150470-09
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Paul D. Bieniasz
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $552,761
- **Award type:** 5
- **Project period:** 2012-09-17 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993265

## Citation

> US National Institutes of Health, RePORTER application 9993265, Core 5 - Virology, Cell, Molecular & Chemical Biology Core (5U54AI150470-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9993265. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*