# Molecular Oncology Program

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $30,962

## Abstract

PROJECT SUMMARY/ABSTRACT
The Molecular Oncology Program represents one of the two basic science fundaments to the University of
California, Davis Comprehensive Cancer Center. The novel discoveries emanating from the program form the
scientific underpinning of the translational and clinical cancer research to develop innovative modalities in the
diagnosis and treatment of cancer.
The two overarching topics of 1) Oncogenic Signaling and 2) Mechanisms of Genome Stability continue
serving well to coalesce an eminent group of investigators into a cohesive program that through collaborations
with one another and with numerous investigators in the other Cancer Center programs ensures that their
discoveries are translated from the bench to the bedside.
The Molecular Oncology Program strategically focuses on in vitro model systems leveraging the strength in
biological research at UC Davis. This approach is complemented by associated in vivo studies using animal
models conducted by the members in the Comparative Oncology Program. A significant pipeline of lead
studies has been brought to clinical trials in cooperation with the Cancer Therapeutics and the Prostate
Urothelial Cancer Program. Extending our strength in DNA repair to the analysis of cancer risk in human
populations is the subject of collaborations with the Population Sciences & Health Disparities Program. A long-
standing collaboration connects the studies in hormone receptor biology with translational and clinical studies
in the Prostate Urothelial Cancer Program. The high-end technology and analysis tools developed and utilized
by members in the Biomedical Technology Program enabled program members to better analyze molecular
and cellular processes.
SCIENTIFIC THEMES
1.Cytoplasmic Signaling and Chromosome Dynamics 2. Nuclear Signaling and Genome Stability
• Nuclear receptors and chromatin remodeling • DNA repair and chromosome segregation
• Oncogenic signals transmitted to the nucleus • Oncogenic signals emanating from the nucleus
PROGRAM ASPECTS
 Co-leaders: Kermit Carraway, PhD, Wolf-Dietrich Heyer, PhD
 Members: 36
 Total Grant Funding (ADC): $9.2 million
 Total Peer-Reviewed Funding (ADC): $8.7 million
 Total NCI funding (ADC): $2.7 million
 Total No. Publications: 464
 Inter-programmatic publications: 102 (22%)
 Intra-programmatic publications: 47 (10%)
 Multi-institutional publications: 219 (47%)
The membership of the Molecular Oncology Program remains at a dynamic steady state of 36 from 12 different
department and 4 different schools at UC Davis, as well as LLNL. The total peer-reviewed, cancer-related
funding (annual direct cost) has slightly declined to $9.2 million (from $10.8 million at the last competitive
renewal) due to sequestration and the departure or retirement of several well-funded senior members.
However, our NCI funding has even slightly increased (from $2.4 to $2.7 million) with 18 projects funded by
NCI (17 at the last competitive renewal). The funding data exclude th...

## Key facts

- **NIH application ID:** 9993303
- **Project number:** 5P30CA093373-18
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Wolf-Dietrich Heyer
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $30,962
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993303

## Citation

> US National Institutes of Health, RePORTER application 9993303, Molecular Oncology Program (5P30CA093373-18). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9993303. Licensed CC0.

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