# Structural & Drug Screening (SDS)

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $329,519

## Abstract

PROJECT SUMMARY/ABSTRACT (STRUCTURE AND DRUG SCREENING)
In the previous CCSG renewal, Structural Biology (SB) and High-Throughput Screening (HTS) were both
approved and funded as new Shared Resources (SRs). During the project period, the independent SRs
frequently coordinated services for University of Michigan Comprehensive Cancer Center (UMCCC) members
to increase the efficiency and impact of cancer-related projects. This collaboration demonstrated the benefit of
working together from project initiation. The SRs and UMCCC leaders viewed the amalgamation of the SR as a
natural progression and a way for members to receive maximum benefit from these vital resources. With support
from UMCCC Senior Leadership, Janet Smith, PhD was joined by Co-Director Vince Groppi, PhD in 2015 when
they formally merged the SRs into one unit. During this process, Medicinal Chemistry (MC) was added to the SR
to meet existing needs of cancer researchers. In 2016, UMCCC approved the establishment of a comprehensive
unified facility, the Structure and Drug Screening (SDS) SR. The SDS SR enables UMCCC members to use
advanced structure-based drug design and/or nonbiased HTS strategies to identify chemical matter that can be
advanced through a milestone-driven research plan resulting in efficient and effective discovery and
development of precision oncology medicines; a strategic goal of UMCCC. This is accomplished by use of three
service disciplines, each of which is guided by an experienced faculty leader: SB, under the direction of Dr.
Smith; HTS, under the direction of Dr. Groppi, and MC under the direction of Andrew White, PhD. The SR's
cohesive activities, services and processes yield four key benefits to UMCCC members: I) projects are advanced
along the translational pipeline, from basic science discoveries into early cancer drug discovery; II) a project
manager guides researchers in the effective and efficient use of appropriate services matched to their needs; III)
an integrated team approach provides researchers a complete, `one-stop' set of expertise for the duration of their
projects; and IV) researchers accrue cost savings from a streamlined administrative support structure.

## Key facts

- **NIH application ID:** 9993323
- **Project number:** 5P30CA046592-31
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** JANET L. SMITH
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $329,519
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993323

## Citation

> US National Institutes of Health, RePORTER application 9993323, Structural & Drug Screening (SDS) (5P30CA046592-31). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9993323. Licensed CC0.

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