# NINDS Stroke Trials Network - Regional Coordinating Center

> **NIH NIH U24** · UNIVERSITY OF MINNESOTA · 2020 · $308,000

## Abstract

Stroke is a common neurological disease and is a growing major public health problem. Although mortality is
declining, it remains the number four cause of none-accidental death in the U.S. It is still the leading cause of
major disability, and as the population ages and becomes more diverse, the number of affected individuals is
expected to significantly grow. The mission of NINDS is to reduce the burden of neurological disease and
stroke. Multicenter clinical trials are key in advancing the science and practice of stroke treatment. National
Institutes of Health funded clinical trials have often suffered from long start up time and delays in completing
the research. Disease specific research consortiums are part of a national trend to improve these deficiencies
by providing a common infrastructure that will facilitate the design, startup, and conduct of multicenter trials,
streamlining site selection, research team organization, and human subject protection. It will minimize the need
to reorganize the research team for every new trial. Enhanced collaboration will result from such a network,
and will function as an incubator for new research and provide a rich environment for research training. The
StrokeNET network was created in 2013 to achieve those goals. The University of Minnesota (UMN) and its
stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of
academic researchers relevant for this field, with depth in various domains of clinical research. It has extensive
experience in implementing research networks, proven as a current member in StrokeNet, and collaboration
with the University of Minnesota hub of SIREN (Strategies to Innovate EmeRgENcy Care Clinical Trials
Network, the NINDS/NHLBI emergency medicine research network), as well as the previous experience and
relationships built by being part of the two previous funding cycles of the NINDS Neurological Emergency
Research Network (NETT). The leaders for this application are experienced in stroke clinical research,
managing research networks, and are experts in the subject matter. The various specialties needed to
collaborate for successful implementation of the trials are already aligned administratively in collaborative units
beyond traditional departments. Within the previous cycle of StrokeNET, our regional center contributed
significantly to the network, participating in seven clinical trials with the total number of subjects recruited
within the top tier of all RCC’s, a very high rate of patient retention, subject follow-up and document
completion. We have actively engaged with 13 hospitals regionally that have recruited patients into network
trials. We have brought two proposals for investigator initiated trials and served on several key committees
within the network. We have trained four StrokeNet fellows and a team member served on the education
committee. Overall, the current stroke program at the University of Minnesota is ...

## Key facts

- **NIH application ID:** 9993571
- **Project number:** 5U24NS107269-03
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** KAMAKSHI LAKSHMINARAYAN
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $308,000
- **Award type:** 5
- **Project period:** 2018-08-15 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993571

## Citation

> US National Institutes of Health, RePORTER application 9993571, NINDS Stroke Trials Network - Regional Coordinating Center (5U24NS107269-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9993571. Licensed CC0.

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