# External and internal controllers of hippocampal SPW-R initiation

> **NIH NIH U19** · STANFORD UNIVERSITY · 2020 · $469,865

## Abstract

Sharp wave ripples (SPW-Rs) are self-organized, synchronized population events in which
hippocampal circuit excitability is markedly and transiently enhanced. The temporal distribution of
SPW-Rs is highly irregular and strongly influenced by behavioral and brain states, indicating the
existence of control mechanisms for the initiation of these population events and the memory
replay which they support. There is accumulating evidence that suggests that SPW-Rs occurrence
is controlled by both extra-hippocampal and intra-hippocampal influences. However, the precise
distal and local circuit mechanisms by which these extra- and intra-hippocampal influences control
SPW-R initiation are unknown. In Project 1, we will perform a comprehensive set of studies which
will provide new information on the precise temporal relationship (through observational
experiments using integrated high-resolution methods) and perturbational influence (using
optogenetic interventions) of key suspected extra- and intra-hippocampal controllers of SPW-R
initiation.

## Key facts

- **NIH application ID:** 9993612
- **Project number:** 5U19NS104590-04
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Attila Losonczy
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $469,865
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993612

## Citation

> US National Institutes of Health, RePORTER application 9993612, External and internal controllers of hippocampal SPW-R initiation (5U19NS104590-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9993612. Licensed CC0.

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