# Routing of SPW-R content via distinct hippocampal output pathways

> **NIH NIH U19** · STANFORD UNIVERSITY · 2020 · $487,324

## Abstract

As synchronous population events SPW-Rs are strongly implicated in the transmission of intra-
hippocampally stored representations to extra-hippocampal targets, supporting the consolidation of
memory at these targets. The primary hippocampal output originates from CA1 pyramidal cells
(CA1PCs), and CA1PCs with specific cortical and subcortical extra-hippocampal targets are
thought to be differentially distributed along the main hippocampal anatomical axes. In turn, recent
studies demonstrated the presence of a large degree of morphological and functional
heterogeneity within the CA1PC populations along these same hippocampal axes, suggesting the
presence of target-specific functional subdivisions within the hippocampal network. However, the
precise anatomical and functional organization, recruitment mechanisms and behavioral relevance
of SPW-Rs along these extra-hippocampal target-specific subdivisions remain unknown. In Project
4, we will perform an extensive set of new correlational and pertubational experiments which will
provide novel insights into CA1PC target-specific SPW-R organization and function.

## Key facts

- **NIH application ID:** 9993615
- **Project number:** 5U19NS104590-04
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** MARK J SCHNITZER
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $487,324
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993615

## Citation

> US National Institutes of Health, RePORTER application 9993615, Routing of SPW-R content via distinct hippocampal output pathways (5U19NS104590-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9993615. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*