# Air Pollution, the Aging Brain and Alzheimer's Disease

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2020 · $601,304

## Abstract

Prevention of cognitive decline and delay of onset of Alzheimer's disease (AD) are public health priorities,
and improving brain health is a firm commitment of the National Institutes of Health. Since ambient air pollution
exposures are pervasive and modifiable, they are an appropriate target for research on brain health. Evidence
for air pollution links to neurodegeneration is accumulating with recent studies implicating fine particulate
matter (PM2.5), ozone (O3), oxides of nitrogen (NOx and NO2) and traffic-related pollution in lower cognitive
function, cognitive decline, incidence of AD and all-cause dementia, and brain atrophy. The effects of air
pollutants on neuropathology in the aging brain are unknown. Deeper understanding of air pollutants as
potential risk factors will lead to better characterization of disease mechanisms. Improvements in public health
will follow since air pollution exposures can be modified by changes in regulations and individual behaviors.
Few epidemiological studies have been well-positioned to overcome many of the inherent weaknesses in
exposure assessment, study design, and outcome data availability, including a unique set of neuropathology
measures, needed to advance our understanding of the role of time-varying air pollution exposures on
cognitive health, AD, and aging. This study is a unique collaboration between leading experts in the fields of
aging and AD research, statistical, and environmental health sciences. It will use a long-term prospective
cohort study design to examine the effects of air pollution on cognitive decline, all-cause dementia and AD
incidence, and brain neuropathologies. It leverages the community-based sample of 5,088 adults free of
dementia at the time of enrollment from the NIA-funded Adult Changes in Thought (ACT) study. ACT is an
outstanding resource representative of the community with prospective, long-term (up to 20 years), and high-
quality cognitive follow-up, careful diagnosis of incident dementia by subtype, and outstanding data availability
including 633 brain autopsies, genetic data, and decades of extensive medical, and residential history data
extending decades prior to study enrollment. We will collect new air pollution measurements to develop for
ACT participants state-of-the-art long-term average air pollution predictions for ambient PM2.5, O3, NOx, and
NO2 of the highest quality to address our study hypotheses. Our overarching goal is to identify air pollution risk
factors and quantify their effects in order to promote healthy aging. This study provides an extraordinary
opportunity to advance our comprehensive understanding of the effects of air pollution exposures on cognition
in the aging brain and on risk of AD. It aligns well with the 2012-2017 NIEHS Strategic Plan by advancing
fundamental research using state-of-the-art exposure science.

## Key facts

- **NIH application ID:** 9993921
- **Project number:** 5R01ES026187-05
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Gail Li
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $601,304
- **Award type:** 5
- **Project period:** 2016-09-30 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993921

## Citation

> US National Institutes of Health, RePORTER application 9993921, Air Pollution, the Aging Brain and Alzheimer's Disease (5R01ES026187-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9993921. Licensed CC0.

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