# Novel Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates

> **NIH NIH U01** · UNIVERSITY OF GEORGIA · 2020 · $584,042

## Abstract

This proposal brings together two PI's and their laboratories with distinct but
overlapping expertise in the glycochemistry, both from the metropolitan Detroit area, with
the aim of developing new and robust technology and methodology for the synthesis of
oligosaccharides and their conjugates, such as might be readily applied by non-
specialists. The proposal focuses on biologically active oligosaccharides from the
microbial glycome and selects particular targets based on the biological relevance and
the chemical challenges they present. The proposal aims to develop new, improved,
and robust general technologies and methodology for glycosylation that will make
glycosylation both more efficient and less wasteful in terms of resources. According to
this paradigm flow and microwave flow methods will be developed for the preparation of
glycosyl donors, acceptors and promotors, and their eventual use in scalable
glycosylation reactions. These technologies will be applied to existing methodologies for
glycosidic bond formation and in conjunction with the novel concepts of recyclable
photochromic glycosyl donors, and of glycosyl donors that are only activated on demand
in the confines of a supramolecular complex combining the donor, acceptor and
activator. The proposal seeks to make all building blocks, promotors and
oligosaccharides on larger scales than have heretofore been possible and to make the
so-formed materials available for use in the broader community, especially by non-
specialist laboratories.

## Key facts

- **NIH application ID:** 9993981
- **Project number:** 5U01GM125271-04
- **Recipient organization:** UNIVERSITY OF GEORGIA
- **Principal Investigator:** Peter R Andreana
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $584,042
- **Award type:** 5
- **Project period:** 2017-08-01 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993981

## Citation

> US National Institutes of Health, RePORTER application 9993981, Novel Methods and Technologies for Synthesis of Biomedically Relevant Carbohydrates (5U01GM125271-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9993981. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*