# Contributio of a novel developmentally-restricted hematopoietic stem cell

> **NIH NIH K01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $178,200

## Abstract

PROJECT SUMMARY/ABSTRACT
The concept of a layered immune system entails the generation of specific functional components of the
immune system at different stages of development. Despite three decades of research, the cellular
mechanisms underlying immune layering have remained elusive. Our lab recently identified the cellular
mechanism contributing to immune layering. Using a lineage tracing mouse model thoroughly characterized in
our laboratory, we discovered a developmentally limited hematopoietic stem (HSC) that gives rise to
developmentally restricted innate-like immune cells. These innate-like immune cells are critical mediators of
immune tolerance and autoimmunity. Building on this discovery, my research interests focus on determining
the developmental mechanisms underlying the establishment of immune tolerance and autoimmune
susceptibility. I aim to define the unique function of this novel hematopoietic stem cell population in establishing
innate immunity during development. I then seek to define the specific phenotypic, functional, and genetic
attribute of immune cells generated from a developmentally-restricted HSC. Lastly, I aim to determine the
effect of perinatal immune insult on developmental hematopoiesis, immune development and autoimmune
disease susceptibility. This work will be conducted in the Institute for the Biology of Stem Cells at UC Santa
Cruz in the lab of Dr. Camilla Forsberg, an expert in hematopoietic stem cell biology. Over the course of my
doctoral training in nutritional sciences and my postdoctoral training in hematopoietic stem cell biology, I have
gained considerable technical and intellectual breadth in developmental, molecular, and cell biology. My
immediate goal is to broaden my training within immunology, including coursework, collaboration with expert
immunology labs at UC San Francisco, and guidance by my co-mentor, Dr. Robert Coffman, a renowned
expert in innate immunology. My long-term goal is to establish an innovative, independent research program at
the interface of development, hematopoiesis and immunology.

## Key facts

- **NIH application ID:** 9993996
- **Project number:** 7K01HL130753-06
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Anna E Beaudin
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $178,200
- **Award type:** 7
- **Project period:** 2016-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9993996

## Citation

> US National Institutes of Health, RePORTER application 9993996, Contributio of a novel developmentally-restricted hematopoietic stem cell (7K01HL130753-06). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/9993996. Licensed CC0.

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