# Core C - Biostatistics Core

> **NIH NIH P01** · UNIVERSITY OF MINNESOTA · 2020 · $196,611

## Abstract

ABSTRACT 
The Biostatistics Core is responsible for providing statistical support to all projects. The Core will lead or assist 
in the development of all study databases and will lead their statistical analysis. The Core will provide analysis 
of DNA methylation data including quality control, data normalization, software selection, and outcome 
analysis, and perform an epigenome-wide association study of DNA samples from approximately 2,000 
smokers in relation to biomarkers of nicotine and carcinogen metabolism. The Core will provide analysis of 
case-control data in relation to biomarkers of metabolism, DNA-damage, and DNA methylation, and perform 
meta-analysis in order to include data/results from outside cohorts such as ARIC. The Core will also provide 
analysis of ethnic differences, smoking differences, and ethnicity by smoking interactions for a large number 
of biomarkers of metabolism, DNA damage and repair, using urine and or DNA samples from individuals 
recruited through the Clinical Core B, or by the projects directly. Most statistical analysis will be performed 
using existing R or SAS procedures. In some cases new statistical methodology may be developed if existing 
statistical procedures are inadequate for analysis.

## Key facts

- **NIH application ID:** 9994210
- **Project number:** 5P01CA138338-10
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** Daniel O Stram
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $196,611
- **Award type:** 5
- **Project period:** — → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9994210

## Citation

> US National Institutes of Health, RePORTER application 9994210, Core C - Biostatistics Core (5P01CA138338-10). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9994210. Licensed CC0.

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