# Core 2:  Animal and Pharmacology

> **NIH NIH U54** · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2020 · $282,864

## Abstract

Animal and Pharmacology Core – Summary 
The studies in this PS-OC will focus on evaluating a spectrum of EGFR- and RAF-targeted therapies in animal 
tumor models of glioblastoma (GBM) and melanoma brain metastases, and the Animal and Pharmacology 
Core will provide critical infrastructure for these studies. The Core will be led by Dr. Jann Sarkaria, who has 
extensive expertise in animal tumor models and by his long-time collaborator, Dr. William Elmquist, who is an 
expert in pharmacokinetic modeling of drug delivery into the brain. The main function of the Core will be to 
manage all aspects of the experiments that involve live animals and, in collaboration with the Administrative 
Core, to manage distribution of biospecimens and imaging data to the appropriate investigators. The Core will 
manage some experiments that are performed expressly for an individual project and others where the 
analysis of imaging and biospecimens will bridge both projects. The Core will have access to the extensive 
Mayo PDX xenograft collection in collaboration with the Mayo SPORE in Brain Cancer Animal Core. The key 
functions of the Core will include: 
1. Develop and manage detailed experimental animal study plans 
2. Pharmacokinetic and CNS distribution analyses of novel therapeutic agents 
3. Perform therapeutic efficacy analyses 
4. Conduct MR and bioluminescence imaging studies

## Key facts

- **NIH application ID:** 9994240
- **Project number:** 5U54CA210180-05
- **Recipient organization:** MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** Jann N. Sarkaria
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $282,864
- **Award type:** 5
- **Project period:** 2016-08-29 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9994240

## Citation

> US National Institutes of Health, RePORTER application 9994240, Core 2:  Animal and Pharmacology (5U54CA210180-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9994240. Licensed CC0.

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