# In situ imaging of collagen degradation activity in multiple myeloma and lung fibrosis mouse model

> **NIH NIH R21** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $189,688

## Abstract

PROJECT SUMMARY
In Situ Imaging of Collagen Degradation Activity in Multiple Myeloma and Lung Fibrosis Murine Models
Collagen, the major structural component of nearly all mammalian tissues, undergoes extensive pathologic
remodeling during many life-threatening diseases such as cancer, fibrosis and a variety of auto-immune diseases
(e.g. rheumatoid arthritis). Since tissue specific collagen remodeling activity is known to correlate with the disease
stages, in situ imaging of such activity can inform disease condition and efficacy of therapeutic treatment. This is
particularly true if image can report the active state of the disease similar to the functional brain imaging. In the
proposed work, based on exciting preliminary data, we plan to develop a series of end templated collagen
hybridizing peptides (CHPs) probes that can facilitate accurate imaging of collagen degradation activity within
hours after injection with clearance time less than a day, ideal for routine animal imaging. In Aim 1, we will design
and synthesize various dimeric CHPs that have low tendency to self trimerize but can hybridize to denatured
collagen at fast binding rate and enhanced clearance from the target site. In Aim 2, we will develop multiple
myeloma and lung fibrosis murine disease models, and demonstrate dimeric CHP's use in assessing the disease
states. Since ECM degeneration is directly related to the debilitating symptoms of patients and the cost of
healthcare system, a new strategy that can be used in animal models to probe the ECM remodeling could
revolutionize development of new therapy benefiting the patient and the society.
 
PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

## Key facts

- **NIH application ID:** 9994401
- **Project number:** 5R21OD026618-02
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Donghoon Yoon
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $189,688
- **Award type:** 5
- **Project period:** 2019-08-15 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9994401

## Citation

> US National Institutes of Health, RePORTER application 9994401, In situ imaging of collagen degradation activity in multiple myeloma and lung fibrosis mouse model (5R21OD026618-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9994401. Licensed CC0.

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