# A Functional Investigation of Structural Variants Associated with Schizophrenia

> **NIH NIH K23** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $190,733

## Abstract

PROJECT SUMMARY
The current project titled “A Functional Investigation of Structural Variants Associated with
Schizophrenia” proposes the investigation of a class of genomic variants associated with schizophrenia risk,
‘structural variants’, using two approaches. First, the function of structural variants will be investigated at the
level of the brain, in post-mortem brain samples obtained from patients with schizophrenia and normal healthy
controls. Second, patients harboring specific structural variants will be recruited for clinical evaluation, including
an assessment of behavior and cognition. This study will allow for the neurobiological and clinical
characterization of an important class of genomic variants that may be contributory to schizophrenia risk. The
proposed investigation has the potential to lead to improved diagnosis of schizophrenia, as well as improved
treatment options, through a ‘precision medicine’ approach of stratifying patients by underlying genetic
variants, to more effectively target existing and novel therapeutics.

## Key facts

- **NIH application ID:** 9995013
- **Project number:** 5K23MH112955-03
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Rebecca Birnbaum
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $190,733
- **Award type:** 5
- **Project period:** 2018-09-25 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9995013

## Citation

> US National Institutes of Health, RePORTER application 9995013, A Functional Investigation of Structural Variants Associated with Schizophrenia (5K23MH112955-03). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/9995013. Licensed CC0.

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