# Johns Hopkins Rheumatic Diseases Resource-based Core Center

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2020 · $767,757

## Abstract

Overall
PROJECT SUMMARY
One of the abiding philosophies of the Johns Hopkins Division of Rheumatology is that the
critical pathway to understanding human autoimmune rheumatic diseases is through the study
of large numbers of well-defined patients, followed over time, with the collection of rich
phenotypic data, mapping disease trajectory, and where possible, acquiring and storing relevant
biological materials from blood and target tissue. This repository of data and samples can then
be used to separate heterogeneous diagnostic groups into more homogeneous subgroups,
using tools that span the entire spectrum of investigation. This P30 will focus on providing the
framework for organizational (oversight, management), operational (recruitment, sampling,
processing), measurement and analytical (statistical, computational, and integrative) expertise
to enable effective clinical and translational research.
The Hopkins RDRCC competitive renewal comprises an Administrative Core (Core A) led by
Drs. Rosen and Bingham, and includes 3 scientific Cores: (i) Core B is the Research
Management and Patient Integrated Data (RAPID) Core, led by Dr. Bingham; (ii) Core C is the
Sample Processing and Immunoassay Research (SPIRE) Core, led by Drs. Casciola-Rosen
and Soloski; and Core D is the Data Science Core, led by Dr. Scott Zeger. The Center is
structured as a matrix, designed to foster collaborative and synergistic discovery by maximizing
access of the diverse research community to data and samples from humans with rheumatic
diseases. Core A will promote efficient, interdisciplinary research throughout the research
community and Cores, and manage the enrichment program. Core B will facilitate studies on
humans with rheumatic diseases, by providing research management and oversight functions,
enhancing research integration with the Epic EHR, and enable patient-centered outcome
research. Core C will provide assistance with patient sample acquisition, processing, storage
and distribution, as well as provision of multiple immunological assays for discovery and
validation of biomarkers and disease pathways. Core D will provide highly innovative tools to
enable analysis of complex longitudinal data in rheumatic disease patients, particularly with the
design and application of Bayesian hierarchical models to identify disease subsets.

## Key facts

- **NIH application ID:** 9996485
- **Project number:** 5P30AR070254-05
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** CLIFTON O BINGHAM
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $767,757
- **Award type:** 5
- **Project period:** 2016-09-08 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9996485

## Citation

> US National Institutes of Health, RePORTER application 9996485, Johns Hopkins Rheumatic Diseases Resource-based Core Center (5P30AR070254-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9996485. Licensed CC0.

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