# Pathways to Cancer Therapeutics

> **NIH NIH T32** · UNIVERSITY OF CINCINNATI · 2020 · $550,112

## Abstract

Project Summary
The opportunities for new and targeted approaches to cancer treatment are growing at an exponential pace.
However, to effectively harness these opportunities requires a pool of researchers who can bridge the divide
between lab-based identification of new therapeutic approaches and actual clinical needs and practicalities of
patient treatment. Currently the pool of individuals with such skills is limited. The Pathways to Cancer
Therapeutics Training Program seeks to address this shortfall by increasing the number of individuals with a
strong training in the areas of cancer biology that underlie identification of new therapeutic approaches, who also
have a true understanding of the challenges and needs associated with translating scientific discovery into the
clinic. The Training Program has two key goals: The first is to provide pre- and postdoctoral trainees with a
rigorous and applied understanding of how basic research in cancer biology can be utilized to identify new drug
targets and more effective therapeutic strategies. The second is to provide the trainees with an understanding
of the challenges and practice of using cancer therapeutics in the clinic. The training will focus on three areas
that are key to development of new therapeutic approaches and are areas of institutional strength in cancer
therapy: cancer metabolism, tumor immunology and the microenvironment, and genome instability and
regulation. A series of multidisciplinary activities are proposed to achieve the goals of the Program. (1) Trainees
will participate in a mentored research project under the direction of one of 26 primary mentors who come from
10 basic science and clinical departments across the University of Cincinnati (UC) and Cincinnati Children’s
Medical Center (CCHMC). The mentors have active, well-funded research programs and extensive mentoring
experience. (2) Trainees undertake formal training that includes didactic coursework, attending seminars, ethics
training and career development activities. The specialized classes lead to a Certificate in Clinical and
Translational Research. (3) Trainees participate in activities in clinical oncology. Each trainee is paired with a
clinical co-mentor with expertise related to the trainee’s research area. The clinical co-mentor participates in the
development of the trainee research project and career plan. In addition, trainees attend Tumor Boards/Grand
Rounds and participate in clinical shadowing experiences with their co-mentor. The Training Program is
administered by Co-Principal Investigators and a Clinical Director with support from business offices within UC.
Three administrative committees provide program evaluation and oversight, support a rigorous trainee selection
process, ensure excellence in training, monitor trainee progress and ensure that trainees represent an ethnically
and scientifically diverse group. There is a strong institutional commitment to the Training Program in the form
of direct ...

## Key facts

- **NIH application ID:** 9996493
- **Project number:** 5T32CA117846-13
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **Principal Investigator:** Carolyn M Price
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $550,112
- **Award type:** 5
- **Project period:** 2006-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9996493

## Citation

> US National Institutes of Health, RePORTER application 9996493, Pathways to Cancer Therapeutics (5T32CA117846-13). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9996493. Licensed CC0.

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