# Shared Resource: High Throughput Screening Facility

> **NIH NIH P30** · RESEARCH INST OF FOX CHASE CAN CTR · 2020 · $92,759

## Abstract

CELLULAR/MOLECULAR ANALYSES SHARED RESOURCE: HIGH THROUGHPUT SCREENING
FACILITY (HTSF)
PROJECT SUMMARY/ ABSTRACT
The High Throughput Screening Facility (HTSF) provides screening platforms and specialized instrumentation
for increased experimental throughput to support the research of Cancer Center members. The HTSF provides
the capability to perform hypothesis-generating discovery research with the major goal of generating insights
that can be pre-clinically and clinically advanced. Under the direction of Erica Golemis, PhD (MT), the HTSF
has 1.0 FTE of staff, that provides access to specialized equipment, expertise, and direct services that enable
investigators to address novel areas of translational research that would be difficult or impossible to pursue
without the liquid handling, assay resources, reagents and experience of the HTSF. In particular, the HTSF
allows investigators to utilize RNAi and compound libraries, and the specialized instrumentation required for
large scale screening with these resources. 27 Cancer Center members used the HTSF in calendar year 2014.
90% of equipment hours logged in the HTSF during 2014 were in support of peer-review funded research. 47
Cancer Center members from all 5 Research Programs used the HTSF in the period 2011-2014. The
experience of the Facility Director, Golemis, is key in implementing state-of-the-art technology and new
approaches. Golemis' leadership coupled with institutional commitment of $40,000 facilitated an upgrade to
the server supporting the ImageXpress Micro automated microscope. Due to the complexity, cost and caliber
of the instrumentation, HTSF services are best facilitated though a centralized Shared Resource. It would be
cost prohibitive to provide each individual research lab the specialized instrumentation available in the HTSF.
Cost analysis has demonstrated that certain types of screens would be 4 to 5 times more expensive when
outsourced to a commercial vendor. The HTSF Manager has been instrumental to this facility since its
inception, and continues to provide stable and expert guidance. The ability to leverage the scientific expertise
of the investigators' laboratory in conjunction with the HTSF technical expertise has allowed for cost-effective
and high quality screening results. Beyond the context of screening, in support of work to establish clinical
correlates or novel technical capabilities, the HTSF works with individual investigators to perform assay
development and execute specific projects requiring wet-bench capacity. This combination of resources
maximizes the utilization of the equipment and expertise housed within the HTSF to advance the research of
Cancer Center members. The HTSF is supported by a Facility Advisory Committee (FAC) that meets at least
annually. Recommendations from the FAC are directed to a governing Facility Parent Oversight Committee
that serves to ensure that the HTSF continues to have resources necessary to provide the highest quality
serv...

## Key facts

- **NIH application ID:** 9996567
- **Project number:** 5P30CA006927-55
- **Recipient organization:** RESEARCH INST OF FOX CHASE CAN CTR
- **Principal Investigator:** ERICA A. GOLEMIS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $92,759
- **Award type:** 5
- **Project period:** 1997-07-01 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9996567

## Citation

> US National Institutes of Health, RePORTER application 9996567, Shared Resource: High Throughput Screening Facility (5P30CA006927-55). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9996567. Licensed CC0.

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