# STUDIES ON INSULIN RECEPTOR ISO FORMS

> **NIH NIH R35** · STANFORD UNIVERSITY · 2020 · $387,254

## Abstract

Insulin and insulin receptor (IR) are involved in metabolism, proliferation and differentiation. In mammals,
two isoforms (IR-A and IR-B) exist due to differences in alternative splicing. Although it was suggested in the
literature that IR-A activation is “mitogenic” and IR-B activation is “metabolic”, in-depth investigations about the
biological roles of the IR isoforms are challenging due to the lack of tools to study the individual effects. Here,
we propose to develop isoform-selective insulin analogues by using a combination of structure-guided
approach and a high-throughput screening approach. These iso-form selective analogues will be developed to
research probes to dissect the roles of each IR isoform. These tools will enable us to answer the following
questions: 1) Do IR isoform mRNA levels correlate with protein levels? 2) Could the same cell have different
isoform ratio overtime to address cellular need? 3) Does IR isoform distribution in vivo follow some type of
logic? and 4) What is the role of each IR isoform in each cell type in vivo? Research progress in this field may
lead to new therapeutic strategies for human diseases.

## Key facts

- **NIH application ID:** 9996718
- **Project number:** 5R35GM125001-05
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Danny Hung-Chieh Chou
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $387,254
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9996718

## Citation

> US National Institutes of Health, RePORTER application 9996718, STUDIES ON INSULIN RECEPTOR ISO FORMS (5R35GM125001-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9996718. Licensed CC0.

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