# The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)

> **NIH NIH U24** · JOHNS HOPKINS UNIVERSITY · 2020 · $1,469,299

## Abstract

The Chronic Kidney Disease in Children (CKiD) Study is a multi-center, cohort study of children aged 6
months to 16 years with mild to moderate impaired kidney function. Two clinical coordinating centers
(CCCs) (at Children's Hospital of Philadelphia and at Children's Mercy Hospital) and a data
coordinating center (at Johns Hopkins Bloomberg School of Public Health) have formed a cooperative
agreement to conduct a prospective study of chronic kidney disease in children. From 2003 to 2018, we
have established links with the central biochemistry laboratory (CBL) at the University of Rochester
which will be maintained were they to be selected for the 2018-2023 cycle, but infastructure is in place
to work with whichever institution is selected. Since its inception in 2003, the scientific aims of CKiD
have been to determine the risk factors for decline in kidney function and to define how progressive
decline in kidney function impacts biomarkers of risk factors for cardiovascular disease; neurocognitive
function and behavior; and growth failure and its associated morbidity. The purpose of this application
is to request funds to continue the cohort study from August 2018 to July 2023. The substantive
scientific aims are described in the application from the collaborating CCCs. This application describes
the role that the Kidney Disease in Children Data Management and Analysis Center (KIDMAC) will
perform as the data coordinating center of the study. We will continue to provide leadership in study
design, coordination and conduct, data management and analytical methodology and thereby enhance
the scientific scope of CKiD. The specific aims of KIDMAC are: 1) to provide biostatistical and
epidemiological study design expertise including methods to extend follow-up after renal replacement
therapy and to introduce noninvasive devices to gather data remotely; 2) to provide the Steering
Committee, the two CCCs, the CBL and the scientific subcommittees with an infrastructure to
coordinate and conduct CKiD research activities; 3) to maintain and enhance the KIDMAC-developed
web-based system to manage the data of CKiD; 4) to provide biostatistical and epidemiological
leadership in the analysis, interpretation and presentation of study-wide initiatives including the
development of methods for the appropriate analyses of the CKiD data (e.g., usage of time since CKD
diagnosis as time scale for analysis, joint survival and longitudinal data analysis, and methods for
causal inferences); and 5) to implement a quality assurance program that integrates expertise in data
management, study coordination, statistical methodology and scientific disciplines. KIDMAC
investigators have expertise in research design, coordination, data management, quality assurance and
epidemiological and biostatistical methods for complex longitudinal and survival data.

## Key facts

- **NIH application ID:** 9997672
- **Project number:** 5U24DK066116-18
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** ALVARO MUNOZ
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,469,299
- **Award type:** 5
- **Project period:** 2003-09-30 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9997672

## Citation

> US National Institutes of Health, RePORTER application 9997672, The Kidney Disease in Children Data Management and Analysis Center (KIDMAC) (5U24DK066116-18). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9997672. Licensed CC0.

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