# 1/1 Urinary Stone Disease Washington University Research Network

> **NIH NIH U01** · WASHINGTON UNIVERSITY · 2020 · $694,600

## Abstract

PROJECT SUMMARY & ABSTRACT
This is an application from the Washington University in St Louis to participate as a Clinical Center of the
Urianry Stone Disease Research Network (USDRN). We proposed three aims to address the specific needs
enumericated in the RFA-DK-15-004. Urinary stone disease (USD) is major health issue causing pain and
suffering to both adults and children. It is also one of the most prevalent and the most expensive urologic
conditions to treat. Nearly 50% of patients experience at least one recurrence over 5 years’ time. Although
increasing fluid intake is generally recommended for stone formers, a Cochrane review found only one study
for secondary prevention (to reduce recurrence). Patients’ adherence to fluid protocol is generally poor.
Ureteral stenting after stone surgeries caused significant pain and lower urinary tract symptoms (LUTS).
Studies are urgently needed to identify risk factors that predict the severity and persistence of stent-related
pain and LUTS, and to mitigate the suffering. There is also a lack of national biorepository devoted to urinary
stone translational research.
We have assembled a multidisciplinary team of adult and pediatric urologists, nephrologists, pain researcher,
clinical trial specialist, behavioral scientist, radiologists, and emergency department researchers to address the
critical research needs of urinary stone disease. We propose the following three specific aims:
Aim 1: To perform a multi-center, prospective randomized, double-blinded placebo controlled trial to study the
impact of increased fluid intake on stone recurrence using individualized water prescriptions
AIM 2: To identify risk factors that predict the severity of stent-related pain and lower urinary symptoms with
the stent in situ, and the persistence of pain and symptoms after stent removal
AIM 3: Establish a biorepository for future translational research studies of urinary stone disease
Collectively these projects are responsive to RFA DK-15-004 as they address defined scientific priorities. We
acknowledge the responsibilities of participating in this multicenter collaborative project.

## Key facts

- **NIH application ID:** 9997675
- **Project number:** 5U01DK110986-05
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Alana Desai
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $694,600
- **Award type:** 5
- **Project period:** 2016-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9997675

## Citation

> US National Institutes of Health, RePORTER application 9997675, 1/1 Urinary Stone Disease Washington University Research Network (5U01DK110986-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9997675. Licensed CC0.

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