# 05 Tissue Biospecimen and Pathology Resource

> **NIH NIH P30** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $945,434

## Abstract

PROJECT SUMMARY: TISSUE BIOSPECIMEN AND PATHOLOGY RESOURCE (TBPR)
The Tissue Biospecimen and Pathology Resource (TBPR) provides a flexible, sophisticated and well-functioning
institutional biorepository for human tissue specimens in conjunction with an advanced research histology core
facility that supports histopathologic characterization of human and animal tissue specimens. The biorepository
Institutional Tissue Bank (ITB) and the Research Histology Facility (RHF) are 2 longstanding, mature, highly
functional CCSG-supported shared resources that comprise the TBPR. The ITB is a CLIA-accredited facility that
provides center members with access to human tissues, blood, and other fluids obtained from consenting
patients under Institutional Review Board-approved protocols. The RHF provides routine and advanced cell- and
tissue-based services to investigators. The TBPR supports the entire spectrum of research studies, including
biomarker studies in clinical trials as well as basic and pre-clinical animal model research. During the last funding
cycle, the ITB recruited board-certified pathologists' assistants to standardize and improve the quality of tissue
collection throughout the institution. This effort continues to support new institutional initiatives and strategic
alliances on clinical trials for the longitudinal collection of tissue and blood specimens for downstream molecular
and immune profiling analyses and the associated implementation of new workflow processes. The TBPR
director is Dr. Ignacio Wistuba, chair of Translational Molecular Pathology, and the co-directors are Dr. Stanley
Hamilton, head of the Division of Pathology and Laboratory Medicine, and Dr. Dipen Maru, a professor in
Translational Molecular Pathology. The TBPR provides key services, including: biospecimen collection,
processing, distribution, and quality control; unique, specialized services, such as histochemical stains,
immunohistochemistry (IHC), tissue microarray, laser-capture microdissection, in situ hybridization, and digital
pathology that utilizes newly acquired, state-of-the-art equipment such as tissue microarrayers, IHC autostainers,
and Aperio slide scanners; and new pathology consultation services. Over the last grant cycle, the ITB collected
637,042 specimens, and the RHF performed 1,069,932 procedures. MD Anderson has supported the TBPR with
capital equipment funds that total $1,783,014 (ITB $385,387; RHF $1,397,627). Since the previous grant cycle,
the ITB and RHL have supported 234 and 499 cancer center members, respectively, and usage was evenly
distributed among all 16 CCSG programs. Peer review-funded research accounts for over 80% of total usage,
and 32% ($614,243) is requested from the CCSG in grant Yr44. The TBPR facilitated the publication of 481
peer-reviewed papers, including 358 (74%) in journals with IF >5, 159 (33%) in journals with IF >10, and 70
(15%) in journals with IF >20. During the next funding cycle, the TBPR will continue to standar...

## Key facts

- **NIH application ID:** 9997799
- **Project number:** 5P30CA016672-44
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Ignacio I. Wistuba
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $945,434
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9997799

## Citation

> US National Institutes of Health, RePORTER application 9997799, 05 Tissue Biospecimen and Pathology Resource (5P30CA016672-44). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9997799. Licensed CC0.

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