# Neurodevelopmental Effects of Perfluorinated Chemicals

> **NIH NIH R00** · YALE UNIVERSITY · 2020 · $245,888

## Abstract

ABSTRACT
This proposal builds on the candidate’s dissertation research that examined the associations between prenatal
exposure to perfluorinated chemicals (PFCs) and three specific neurodevelopmental outcomes, including
autism, attention-deficit/hyperactivity disorder, and cerebral palsy in the Danish National Birth Cohort (DNBC)
that consists of ~100,000 mothers and children. PFCs are widespread persistent organic pollutants, and
pregnant women and fetuses are often involuntarily and nearly ubiquitously exposed to these synthetic
compounds since the 1950s. Animal studies suggest that PFCs are developmental toxicants but evidence from
human studies is sparse. Decade long collaborations between UCLA and Aarhus University enabled the
candidate to gain access to the unique, large-scale, nationwide Danish cohorts and registries for research. The
proposed study will greatly expand the use of DNBC and various Danish registers and allow for the very first
time examination of the link between prenatal PFC exposures and an array of neurodevelopmental outcomes
never investigated before, including (1) extensive neuropsychological assessments of intelligence, cognition,
attention, memory and motor skills in children at age 5; (2) hospital diagnosis of epilepsy; (3) the child’s social
competence and mental health at age 11; and (4) intellectual capacity and school performance up to age 16.
The proposed studies will capitalize upon the valuable resource of stored maternal pregnancy blood samples
from DNBC, allowing a reliable and valid assessment of PFC exposure levels during fetal development.
The proposal will be pursued within the context of a strong ongoing collaboration between the UCLA
Department of Epidemiology and Aarhus University, adding new partners from the UCLA Medical Psychology
Assessment Center (MPAC) and Department of Human Genetics. This application builds on Dr. Liew’s
expertise in environmental sciences and advanced epidemiologic methods. It will allow him to newly gain the
necessary training in clinical psychology, environmental statistics, and neurobehavioral epi/genetics and to build
a skillset compatible with conducting future cutting-edge epi-gene/environment interactions research that
optimally uses existing large bio-sample repositories in the Nordic countries. Drs. Beate Ritz and JØrn Olsen
have agreed to mentor the candidate through the K99 process. Dr. Robert Asarnow will provide training in
administrating/scoring complex neuropsychological instruments and clinical knowledge of neuropsychiatric
disorders. Dr. Michael Jerrett will provide training opportunities in environmental statistics and exposure
assessment referred to as the ‘external exposome’. Dr. Steve Horvath will provide training in advanced
gene-environment and epigenetic network analysis. The contents of this application provide a strategy to
position the candidate to successfully launch into a tenured professor track position and equip him with the
necessary skills t...

## Key facts

- **NIH application ID:** 9997918
- **Project number:** 5R00ES026729-05
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Zeyan Liew
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $245,888
- **Award type:** 5
- **Project period:** 2018-09-22 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9997918

## Citation

> US National Institutes of Health, RePORTER application 9997918, Neurodevelopmental Effects of Perfluorinated Chemicals (5R00ES026729-05). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/9997918. Licensed CC0.

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