# Yale Clinical and Translational Science Award

> **NIH NIH UL1** · YALE UNIVERSITY · 2020 · $8,408,317

## Abstract

Contact PD/PI: Sherwin, Robert S.
1. Overall
Project Summary- The Yale Center for Clinical Investigation (YCCI) was created in 2005 to strengthen Yale's
infrastructure for clinical and translational research, based on the recommendation of a Medical School
strategic planning committee. Soon afterwards, when NIH launched its new program of Clinical & Translational
Science Awards, YCCI applied and became the home of the Yale CTSA. Since then, one of its major priorities
has been to support the education and career development of the next generation of clinical and translational
investigators. As described in the present application, this initiative has met with great success, underscored
by the fact that graduates of YCCI's K-Scholar program have received 47 individual NIH K Awards, 43 NIH
RO1 awards, and 65 Foundation grants, published >1,800 papers, and obtained >$240 million in independent
research funding. Remarkably, 98% of the program's graduates have stayed in academic medicine or pursued
research careers in the biotech or pharmaceutical industries. YCCI has also made substantial progress in its
push to accelerate the translation of disease-related discoveries into the clinic. As will be described, it provides
Yale investigators with key assistance in areas including biostatistics and bioinformatics, study design, protocol
development, regulatory approval, patient recruitment, access to inpatient and outpatient research facilities,
and budgeting support, and gives them ready access to pilot grants and state-of-the-art research cores. The
result has been a significant upsurge in the number and scope of clinical research projects throughout the
Medical Center.
In the next grant cycle, YCCI will build upon these achievements with an emphasis on team-based T1 to T4
research, including studies across the lifespan. YCCI will also pursue new partnerships with the Yale School of
Engineering & Applied Science to develop an innovative technology transfer program called the Center for
Biological and Innovative Technology (CBIT) and with the School of Organization & Management to offer a
novel program of leadership training for clinicians and physician-scientists. In addition, YCCI will take active
advantage of the recent expansion of clinical services by Yale-New Haven Hospital (YNHH), which now has
1,540 beds and more than 1 million outpatients visits per year, and the growth of the Yale Medical Group
(YMG), which has a network of >1,200 practicing physicians in >100 clinical specialties. The resulting clinical
volume (~4 million patient records) gives Yale researchers access to a large, diverse patient base for
outcomes studies and clinical trials. Overall, YCCI will leverage Yale's outstanding scientific and clinical
environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop
innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the
benefit of the he...

## Key facts

- **NIH application ID:** 9998047
- **Project number:** 5UL1TR001863-05
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** John H. Krystal
- **Activity code:** UL1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $8,408,317
- **Award type:** 5
- **Project period:** 2016-07-01 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998047

## Citation

> US National Institutes of Health, RePORTER application 9998047, Yale Clinical and Translational Science Award (5UL1TR001863-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9998047. Licensed CC0.

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