# A New Drug Therapy for Advanced Heart Failure

> **NIH NIH R44** · CORNOVUS PHARMACEUTICALS, INC. · 2020 · $968,717

## Abstract

PROJECT SUMMARY
Current therapy for advanced heart failure (HF) is limited and new treatment is needed since the
mortality and morbidity of subjects with this form of heart disease remain high. Effort aimed at
enhanced healing of failing heart by cardioprotection represents a novel approach. The specific
background for the proposed project is that we have identified the endogenous cardiac P2X
receptor as a new therapeutic target for cardioprotection. The cardiac P2X4 receptor is an
essential and important subunit of the endogenous cardiac P2X receptor. A small molecule drug
substance MRS2339 activating cardiac P2X receptors has proven preclinical efficacy in animal
models of advanced HF and is without safety concerns in the Investigational New Drug (IND)-
enabling studies in rat and dog. Cornovus is a company, in collaboration with its academic
partner University of Connecticut School of Medicine’s cardiology research laboratory and
Laboratory of Bioorganic Chemistry of the National Institute of Diabetes, Digestive and Kidney
Diseases of NIH, is well-positioned to apply for an IND to the Food and Drug Administration
(FDA) should the proposal is awarded. The objective of the grant is to further develop process
chemistry for bulk cGMP manufacturing of the clinical lot of MRS2339 and its drug product
based on the current formulation as well as to perform FDA-requested in vitro studies on cardiac
ion channels and on potential mitochondrial toxicity by MRS2339 and its metabolite MRS1873.
Cornovus has already improved the scale-up process chemistry in producing hundred gram
quantity for GLP safety studies and has ruled out any effect on the human ether-à-go-go-related
gene (hERG) ion channel by both compounds. The proposed studies should add to scientific
knowledge on the chemistry and pharmacology of both compounds and may also yield new
insights into the science of nucleotide and nucleoside. The proposal should also satisfy the
regulatory requirements to move this new drug into first-in-human clinical study, as we
anticipate new benefit to patients with advanced HF.

## Key facts

- **NIH application ID:** 9998080
- **Project number:** 1R44HL152710-01
- **Recipient organization:** CORNOVUS PHARMACEUTICALS, INC.
- **Principal Investigator:** Terence Kelly
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $968,717
- **Award type:** 1
- **Project period:** 2020-07-15 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998080

## Citation

> US National Institutes of Health, RePORTER application 9998080, A New Drug Therapy for Advanced Heart Failure (1R44HL152710-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9998080. Licensed CC0.

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