# Multi-omic networks associated with COPD progression in TOPMed Cohorts

> **NIH NIH R01** · UNIVERSITY OF COLORADO DENVER · 2020 · $824,479

## Abstract

PROJECT SUMMARY
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the US. Although
COPD occurs predominantly in smokers, it is unknown why only a minority of smokers (~20-40%)
develop chronic airflow limitation or destruction of distal airspaces (emphysema). The difference
susceptibility to tobacco smoke could be explained by differences in genetics or environment, which
lead to activation or repression of pathways that are important in the pathogenesis and progression of
COPD. Recent advances in high throughput omics (whole genome sequencing, DNA methylation,
RNA-Seq, proteomics and metabolomics) applied to NHLBI cohorts now permits a comprehensive
assessment of the molecular profiles of susceptible patients. This proposal will use sparse multiple
canonical correlation network analysis (SmCCNet) to integrate these existing -omics data from three
NHLBI cohorts: COPDGene, Jackson Heart Study, and SPIROMICS. The three independent cohorts
will allow replication of specific molecular networks which can be used to target new therapies or more
precise prognostic information to individuals (i.e., precision medicine). The first two of these cohorts
have large numbers of African American subjects, who are underrepresented in omics studies. We will
perform population specific analyses, which will allow us to determine which molecular signatures and
pathways might be specific to African Americans.

## Key facts

- **NIH application ID:** 9998187
- **Project number:** 1R01HL152735-01
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** RUSSELL Paul BOWLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $824,479
- **Award type:** 1
- **Project period:** 2020-04-05 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998187

## Citation

> US National Institutes of Health, RePORTER application 9998187, Multi-omic networks associated with COPD progression in TOPMed Cohorts (1R01HL152735-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9998187. Licensed CC0.

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