# Genomics_and_Proteomic-Core

> **NIH NIH U54** · CHILDREN'S RESEARCH INSTITUTE · 2020 · $173,761

## Abstract

The goal of the Genomics and Proteomics Core (GPC) is to develop and implement cutting edge genomics
and proteomics technologies - including bioinformatics - to support intellectual and developmental disability
(IDD) research projects in the Washington DC metropolitan area (DC-IDDRC) and nationally through
collaboration with other IDDRC centers. Support provided by the core includes both routine and specialized
services to meet the need of DC-IDDRC investigators. The genomics services include conventional
technologies (expression, SNP and methylation arrays) and newly implemented next-generation sequencing
(NGS) of DNA/RNA on Illumina and Pacific BioSystems platforms. For the proteomics components, the core
has standardized highly innovative and sensitive quantitative proteomic techniques using a combination of
stable isotope labeling by amino acid in cell culture (SILAC) and in vivo in mice (SILAM), and provided them as
services to DC-IDDRC investigators. Supported research projects include studies on neurodevelopmental
disorders, brain injury (especially fetal and neonatal), and genetic disorders. A major strength of the GPC is the
continuous upgrade of instrumentation and methods to keep pace with rapidly changing technology and
investigator needs. Critical to this new U54 application, the GPC will help investigators transition their basic,
translational and clinical research projects from bench to bedside. A close collaboration with the new Clinical
Translational Core, as well as other DC-IDDRC Cores as needed, will facilitate this goal. One example, which
is the focus of this new RFA, is development of noninvasive biomarkers to monitor disease progression and
response to therapies in clinical trials. The core has developed highly accurate and highly multiplexed methods
for discovery and validation of biomarkers in IDD-related diseases. We also propose a broad strategy for multi-
level integrative analysis of “omics” data, from DNA to proteins, utilizing substantial established computational
infrastructure, together with newly emerging tools. Pipelines developed as part of this effort will be freely
available through deposition in public resources. Overall, the objectives of the GPC are to: 1. Deliver
individualized, full service, cost-effective assistance in state-of-the-art genomic and proteomic technologies to
investigators engaged in research relevant to IDD; 2. Implement novel and emerging “omics” approaches to
enhance IDDR at the DC-IDDRC, and provide training and education about these technologies to DC-IDDRC
investigators; and 3. Synergize and collaborate with other DC-IDDRC cores, DC-IDDRC investigators, the
focused research project, and other IDDRCs to strengthen and enhance multidisciplinary IDDR.

## Key facts

- **NIH application ID:** 9998686
- **Project number:** 5U54HD090257-05
- **Recipient organization:** CHILDREN'S RESEARCH INSTITUTE
- **Principal Investigator:** ERIC P. HOFFMAN
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $173,761
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998686

## Citation

> US National Institutes of Health, RePORTER application 9998686, Genomics_and_Proteomic-Core (5U54HD090257-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9998686. Licensed CC0.

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