# Neurobehavioral_Evaluation-Core

> **NIH NIH U54** · CHILDREN'S RESEARCH INSTITUTE · 2020 · $217,380

## Abstract

The proposal responds to RFA-HD-14-012 by providing core services that advance the diagnosis, prevention,
treatment, and amelioration of intellectual and developmental disabilities (IDD). The primary aim of the NEC is
to leverage standard and cutting edge neurobehavioral and cognitive approaches to further our understanding
of healthy and diseased brain anatomy, function, and pathophysiology. In order to realize this goal,
measurement of neurobehavioral and cognitive outcomes is a crucial endpoint for studies of both atypical and
typical development. The aims of the studies supported by the NEC, therefore, focus on developmental,
cognitive, and behavioral outcomes in animal models of IDD and in children who have a variety of
neurogenetic, neurodevelopmental, or acquired neurological disorders. Furthermore, advancement in the
diagnosis, prevention, treatment, and amelioration of IDD is maximized through a multi-level, translational,
approach that progresses from preclinical (animal) to human studies. Overall, the goal of the NEC is to guide
investigators to use neurobehavioral/cognitive testing to assist in defining specific, yet complex,
neurobehavioral and neuropsychological processes. Aims of the NEC are to: AIM 1: Provide services at a
level appropriate to individual projects including maximizing test and technology development; AIM 2:
Provide individual and group education and training to the DC-IDDRC community; and AIM 3: Promote
and facilitate Core collaboration across projects. The importance of the NEC is to employ measures that
link the underlying mechanisms of neurological disorders with behavioral and cognitive developmental
outcomes. The NEC affords DC-IDDRC investigators access to a robust platform to improve access to state-
of-the-art neurobehavioral and cognitive tools and to enhance the overall quality of preclinical and clinical
neurobehavioral research being conducted throughout the DC-IDDRC. In addition, the Core improves
efficiency by providing access to expert personnel and/or testing materials that maximize cost effectiveness.

## Key facts

- **NIH application ID:** 9998689
- **Project number:** 5U54HD090257-05
- **Recipient organization:** CHILDREN'S RESEARCH INSTITUTE
- **Principal Investigator:** GERARD A. GIOIA
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $217,380
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998689

## Citation

> US National Institutes of Health, RePORTER application 9998689, Neurobehavioral_Evaluation-Core (5U54HD090257-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9998689. Licensed CC0.

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