# Telerehabilitation Combining Virtual Reality Adaptable Games and Drug Therapy for Early Alzheimer's Disease

> **NIH NIH R43** · BRIGHT CLOUD INTERNATIONAL CORPORATION · 2020 · $204,785

## Abstract

PROJECT SUMMARY
Objectives: The first objective is to develop a computer-based cognitive training system for individuals in
the early stages of Alzheimer’s Disease. The product, a home-based custom Virtual Reality (VR) system
will be developed, targeting cognitive domains (processing speed, executive functions, attention, language,
memory) as well as depression. The system will incorporate a novel low-cost biosensor device. Usability
and feasibility studies of the product will determine technology ease of use, acceptance and clinical benefit.
Specific Aims: 1) Development, validation and usability evaluation of an integrative therapy system;
2) RCT Feasibility study on individuals with cognitive impairments due to Alzheimer’s Disease, who may
also be depressed.
Methods: 1) Develop a system to detect cognitive load variation during computer interaction; 2) Develop
VR-based therapeutic games with focus on cognitive intervention; 3) Develop communication software to
allow remote management of the game system with training data transfer; 4) Conduct validation on n=2,
and a usability study n=4 (2 healthy and 2 with AD); 5) Conduct an RCT feasibility trial with cross-over
design, n=28 participants with AD and their 28 caregivers. Participants will be randomized equally into
experimental and wait-list controls. Caregivers will log training issues and perceived value of training; 6)
Sample standardized outcome measures at baseline, mod- and post-therapy. 7) Analyze adherence to
protocol and outcome data using descriptive and multivariate regression analysis to determine cognitive
benefits and group changes, when combined with customary care.
NIH Relevance: Current medication treatments for cognitive impairments subsequent to AD benefit from
addition of physical exercise. The proposed home-based cognitive intervention is an innovative approach,
provided in the convenience of home. This increases access to care with less caregiver burden.

## Key facts

- **NIH application ID:** 9998827
- **Project number:** 5R43AG065035-02
- **Recipient organization:** BRIGHT CLOUD INTERNATIONAL CORPORATION
- **Principal Investigator:** Grigore C BURDEA
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $204,785
- **Award type:** 5
- **Project period:** 2019-09-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998827

## Citation

> US National Institutes of Health, RePORTER application 9998827, Telerehabilitation Combining Virtual Reality Adaptable Games and Drug Therapy for Early Alzheimer's Disease (5R43AG065035-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9998827. Licensed CC0.

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