# Core I: Pharmacology Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $101,895

## Abstract

The UCSF-Gladstone CFAR Pharmacology Core has provided state of the art pharmacological tools for
HIV-associated research for over 30 years, with the overarching goal of optimizing treatments for HIV-
infected subjects. T the Core is the home-base for long-standing scientists and staff who support CFAR
investigators through analytical assay development, pharmacological trial design, and sample and data
analysis for preclinical and clinical pharmacokinetic (PK) and pharmacodynamic (PD) studies. In the
last five years, the Pharmacology Core analyzed over 27,000 samples, contributed to 44 published
manuscripts, provided mentoring and training to 24 faculty, fellows, and students, and supported 35
investigations led by 32 investigators. The Core responded to the changing needs of CFAR
investigators by introducing 26 new assays and services and actively supported CFAR scientific
priorities including treatment for HIV, TB, and malaria, particularly internationally, and inflammation and
latency. In addition to strong support toward domestic CFAR initiatives, the Core is heavily integrated
with CFAR sponsored international research including with programs in Kampala and Tororo, Uganda;
Kisumu, Kenya; and Harare, Zimbabwe. The Core continuously evolves to maintain a broad array of
cutting-edge pharmacological assays including methods to quantitate the most current drugs used in
HIV patients based on plasma, intracellular, and tissue-based assays.
The Core focuses on three complementary efforts that together provide added value to CFAR-affiliated
investigators–
 1) Supporting CFAR investigators with specialized pharmacological methodologies and expertise
 in study design or data analysis customized to their needs;
 2) Advancing synergy by supporting translational research relevant to CFAR Scientific Priorities;
and
 3) Providing education and training in pharmacological analytical methods, study design and
 analysis for next generation translational scientists, both domestically and internationally.

## Key facts

- **NIH application ID:** 9998840
- **Project number:** 5P30AI027763-29
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** FRANCESCA T. AWEEKA
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $101,895
- **Award type:** 5
- **Project period:** 1997-03-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998840

## Citation

> US National Institutes of Health, RePORTER application 9998840, Core I: Pharmacology Core (5P30AI027763-29). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9998840. Licensed CC0.

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