# Core C: Bioinformatics

> **NIH NIH P50** · SLOAN-KETTERING INST CAN RESEARCH · 2020 · $178,584

## Abstract

The Bioinformatics Core will provide services that are vital to many of the projects with in the SPORE in
Prostate Cancer, including the application and development of statistical and computational techniques to
process next-generation sequencing data from a variety of applications. The Core can apply standard
processing algorithms and pipelines to a large number of samples. Additionally, the personnel of this Core
have the expertise to create and deploy custom methods and applications as needed by the SPORE
researchers. Members of the Core can leverage their experience in processing the large amount of genomic
data at Memorial Sloan Kettering Cancer Center (MSKCC) to provide SPORE projects with state-of-the-art-applications
with very little development time or effort; thus, greatly reducing the time and cost required for
individual projects to develop their own analysis pipelines. The specific aims of the Bioinformatics Core are:
Aim 1. To develop and provide state-of-the-art genomic analysis pipelines for:
• the detection of variants in targeted-DNA assays, MSK-IMPACT (Integrated Mutation Profiling of
Actionable Cancer Targets) and whole exome sequence (WES). This pipeline will detect both single
nucleotide changes and small insertion deletions for both somatic- and germline-variant calling
scenarios.
• DNA copy number analysis, which can measure both total copy number changes and allele-specific
copy number, including loss of heterozygosity (LOH).
Aim 2: To facilitate the sharing of data generated in the SPORE research projects and enable collaboration of
integrative analysis via the MSKCC cBioPortal by collecting, formatting, and importing data generated by these
research projects into the cBioPortal.

## Key facts

- **NIH application ID:** 9998852
- **Project number:** 5P50CA092629-20
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **Principal Investigator:** Nicholas D Socci
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $178,584
- **Award type:** 5
- **Project period:** 2001-09-14 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998852

## Citation

> US National Institutes of Health, RePORTER application 9998852, Core C: Bioinformatics (5P50CA092629-20). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9998852. Licensed CC0.

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