# Core D: Animal Models

> **NIH NIH P50** · SLOAN-KETTERING INST CAN RESEARCH · 2020 · $161,780

## Abstract

The overall purpose of the Animal Models Core (Core D) is to facilitate the accomplishment of the translational
research goals and objectives of the SPORE by providing investigators with assistance in the design and
generation of transgenic and knockout/knockin mouse strains, a centralized repository for these mouse strains,
and material of common interest, such as dissected tissues, DNA, RNA, or protein extracts from these mouse
strains.The specific aims of the Animal Models Core are to:
1. Generate and provide genetically engineered mouse models and patient-derived xenograft models as needed
by SPORE investigators.
2. Provide small animal imaging, histopathologic analyses of tumor specimens, design and conduct
preclinical trials, and serve as a repository and breeding service of mouse strains as requested
by SPORE investigators.
3. Provide SPORE laboratories with dissected tissue specimens, DNA, RNA, and proteins from the
various mouse models utilized by our investigators.

## Key facts

- **NIH application ID:** 9998853
- **Project number:** 5P50CA092629-20
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **Principal Investigator:** Brett Stewart Carver
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $161,780
- **Award type:** 5
- **Project period:** 2001-09-14 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998853

## Citation

> US National Institutes of Health, RePORTER application 9998853, Core D: Animal Models (5P50CA092629-20). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9998853. Licensed CC0.

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