# Animal Barrier

> **NIH NIH P30** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2020 · $155,290

## Abstract

PROJECT SUMMARY – ANIMAL BARRIER SHARED RESOURCE
The Animal Barrier Shared Resource (ABSR) provides specific pathogen-free (SPF) rodent housing and
services that are critical to the research of Albert Einstein Cancer Center (AECC) members and the Center's
programmatic activities. The ABSR is a component of the Institute of Animal Studies (IAS), Einstein's AAALAC
accredited animal care & use program. The ABSR provides a broad spectrum of animal husbandry services
including: veterinary care, comprehensive rodent quality assurance and quarantine programs. There is an
intensive program of instruction for AECC members and their trainees prior to allowing access to the facilities
to implement matings, genotype progeny, characterize mouse phenotypes, implant tumors and measure their
growth, administer drugs, and obtain tissue biopsies. AECC investigators maintain breeding colonies of novel
mouse strains bearing transgenes or targeted mutations relevant to cancer biology. Their research also
involves complex breeding schemes to recombine specific alleles from different genetic loci into a limited set of
genotypes on a single strain background. Many AECC investigators use immune deficient mice that tolerate
human tumor xenografts as models to study tumorigenesis, angiogenesis, invasion, and metastasis, as well as
to test anti-neoplastic therapies in human cancers. AECC members account for most of the total ABSR usage
(cage care-days). The ABSR includes three SPF rodent housing facilities with an overall SPF mouse housing
capacity of 25,000 cages. Personnel include three faculty Laboratory Animal Veterinarians (including the
Director), an Operations Manager, three Facility Supervisors, four Veterinary Technicians, office staff, and
approximately 42 Animal Caretakers.

## Key facts

- **NIH application ID:** 9998870
- **Project number:** 5P30CA013330-48
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** LAWRENCE H HERBST
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $155,290
- **Award type:** 5
- **Project period:** 1997-06-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998870

## Citation

> US National Institutes of Health, RePORTER application 9998870, Animal Barrier (5P30CA013330-48). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9998870. Licensed CC0.

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