# Molecular Cytogenetics

> **NIH NIH P30** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2020 · $61,473

## Abstract

PROJECT SUMMARY - MOLECULAR CYTOGENETIC SHARED RESOURCE
The Molecular Cytogenetic Shared Resource (MCSR) provides tools for the preparation of human and
murine samples suitable for molecular genetics and cytogenetics analysis of the entire genome. The goal is to
provide AECC investigators with the whole spectrum of services necessary to analyze the genome at various
levels of resolution. These services include the establishment of EBV transformed cell lines, and enrichment of
blood cell subtypes that can be cryopreserved and stored in liquid nitrogen. Isolation of DNA and mRNA from a
variety of tissue culture samples as well as primary biopsies is also provided. A full panel of services is
provided, from preparation of metaphase chromosomes to the generation of custom designed probes and
hybridization for the detection of copy number and structural chromosomal alterations. The MCSR provides
analyses at all cytogenetic levels of resolution from standard to spectral karyotyping, and from whole
chromosome paints to locus-specific probes for unique regions of the genome. A recently developed targeted
sequencing panel for the mutational analysis of caretaker and gatekeeper genes is now also offered for studies
at single nucleotide resolution of the cancer genome. MCSR personnel are trained to design targeted, locus-
specific probes for regions of interest to investigators. All probes are custom designed and generated in-house.
The MCSR also performs hybridizations on paraffin-embedded tissues as well as image acquisition and full
data analysis.

## Key facts

- **NIH application ID:** 9998882
- **Project number:** 5P30CA013330-48
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Cristina Montagna
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $61,473
- **Award type:** 5
- **Project period:** 1997-06-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998882

## Citation

> US National Institutes of Health, RePORTER application 9998882, Molecular Cytogenetics (5P30CA013330-48). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9998882. Licensed CC0.

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