# Structural Biology

> **NIH NIH P30** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2020 · $139,665

## Abstract

PROJECT SUMMARY - STRUCTURAL BIOLOGY SHARED RESOURCE
The Structural Biology Shared Resource (SBSR) provides comprehensive services and technologies for the
generation of high resolution structural (X-ray, NMR, Cryo-EM) and proteomics analyses, and the technical
expertise and intellectual infrastructure for interpretation and leveraging of these data to drive biochemical, cell
biological and genetic experiments to discover novel biological processes and targets that lead to new
therapeutic strategies. These traditional structural and proteomics methods are complemented by a wide range
of computational, biochemical and biophysical approaches within Einstein and the AECC. The SBSR also
provides considerable expertise in protein science, offering state-of-the-art automated capabilities in protein
expression and purification, and receptor-ligand interaction analysis. Over the past funding period there have
been significant technical, leadership, administrative and organizational enhancements. (i) The current AECC-
supported Proteomics resource has been merged into the Structure Biology Shared Resource (SBSR) to
capitalize on the scientific, technical and administrative synergies of this union, and an exceptional Proteomics
co-director, Simone Sidoli from the U. of Penn, has been recruited. As part of this recruitment, the College has
committed to the purchase of state-of-the-art instrumentation; (ii) A new senior co-director, David Cowburn,
was recruited to lead the NMR component, providing enhanced capabilities in NMR and enhanced access to
the New York Structural Biology Center with its expanded world-class cryo-electron microscopy infrastructure;
(iii) There is now extensive access to the unique X-ray diffraction infrastructure at the newly established
National Synchrotron Light Source-II (NSLS-II) at Brookhaven National Laboratory, as well as continued
access to resources at Argonne National Laboratory; (iv) a new in-house X-ray data collection system was
obtained through an NIH shared instrumentation grant; and v) with College support, high-throughput CRISPR
screening and mAb discovery platforms have been implemented in association with the SBSR. Taken together,
this unique set of technologies, and associated expert technical staff, supports a broad spectrum of studies on
fundamental mechanisms underlying cancer biology, and enables the development of small molecules and
biologics for novel treatment strategies that have resulted in considerable intellectual property and
commercialization opportunities.

## Key facts

- **NIH application ID:** 9998883
- **Project number:** 5P30CA013330-48
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** STEVEN C. ALMO
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $139,665
- **Award type:** 5
- **Project period:** 1997-06-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998883

## Citation

> US National Institutes of Health, RePORTER application 9998883, Structural Biology (5P30CA013330-48). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9998883. Licensed CC0.

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