# Biospecimen Bank

> **NIH NIH P50** · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2020 · $170,878

## Abstract

Core C is designed to meet the specific needs of the projects and at the same time draw on the strength of the
existing Cancer Center (CC) cores without unnecessary duplication of services. This Core will work closely and
synergistically with a number of CC Cores as well as other SPORE Cores to provide exceptional support for all
the proposed projects and possible inter-SPORE collaborations.
The overarching goals of this core is to provide high quality, well annotated and strictly quality controlled
biospecimens for the projects, to develop and implement assays needed for the analysis of the biospecimens
and to collaborate with Core B to build the informatics infrastructures to facilitate all aspects of research linked
to biospecimens.
Specific Aim 1 is to provides services in the following areas: (1) acquisition and banking of fresh and paraffin-
fixed tissues of lymphoma and blood and bone marrow (BM) samples obtained prospectively and
retrospectively from patients enrolled on the COH lymphoma SPORE; we will ensure rapid collection and
processing, proper storage and monitoring, and proper annotation and record keeping; (2) comprehensive
work-up of lymphoma specimens to ensure correct diagnosis and classification, including
immunohistochemical, flow cytometric, molecular pathologic, and cytogenetic studies; (3) performance and
assistance in routine histologic and immunohistochemical staining of lymphoma tissues and cells, as well as
specialized histologic services such as preparation of multi-tumor blocks or tissue microarrays to the
specifications of researchers. Additional specialized services will be performed according to the needs of the
projects with the collection of leukapheresis specimens to generate CAR-T cells (Project 1); characterization of
complex Hodgkin lymphoma and host cell populations through multispectral multiplexed immunofluorescence
(mIF) phenotyping and gene expression profiling (GEP) (Project 3); cytogenetic and genomic characterization
of lymphomas and the preparation of samples to generate primary patient-derived xenograft (PDX) non-
Hodgkin lymphoma models (Project 4).
Because of the complexity of the datasets associated with the functions of Core C, in Specific Aim 2, we will
collaborate with Core B (Research Informatics) to design, build, and integrate databases relevant to
biospecimens to improve their functionality and connectivity to support SPORE projects and collaborations on
other NCI-sponsored projects.

## Key facts

- **NIH application ID:** 9998902
- **Project number:** 5P50CA107399-13
- **Recipient organization:** BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- **Principal Investigator:** Wing C. Chan
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $170,878
- **Award type:** 5
- **Project period:** 2004-09-02 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9998902

## Citation

> US National Institutes of Health, RePORTER application 9998902, Biospecimen Bank (5P50CA107399-13). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9998902. Licensed CC0.

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