# Viral Pathogenesis Core

> **NIH NIH P30** · NORTHWESTERN UNIVERSITY · 2020 · $272,894

## Abstract

PROJECT SUMMARY
THIRD COAST CFAR CORE E: VIRAL PATHOGENESIS CORE (VPC)
The Viral Pathogenesis Core (VPC) brings highly sophisticated tools, services and reagents of biological HIV
research to the interdisciplinary research teams of the TC CFAR. The largest number of VPC users address
Overall aim 3: to discover/develop scientific innovations that better prevent HIV and improve treatment of all
conditions for persons living with HIV (PLWH). We provide, and are enhancing, consultation and training to
facilitate the ability of our diverse teams spanning the breadth of HIV research disciplines at the University of
Chicago and Northwestern University to contribute to development of new biological interventions that will
reduce transmission of HIV, address the increased risk of chronic diseases of aging in the HIV+ population, and
advance HIV cure research. VPC has already strongly grown opportunities for adding biological tools to the work
of clinical and behavioral HIV researchers addressing Overall aims 1 (improving HIV prevention and care
continuums) and 2 (non-AIDS co-morbidities). New activities will add engagement of laboratory researchers
studying aging biology and aging-related disorders who are interested in collaborations on aging in HIV, in
support of Overall aim 2. The specific aims of the VP Core are: 1) provide an expanding menu of virological,
imaging and immunological assays, as well as consultation and navigation to other disciplines and technologies,
that will advance innovative, interdisciplinary HIV research; 2) provide expert design/performance of HIV
experiments, as well as consultation/navigation on imaging, systems biology, -omics; 3) strengthen information
exchange and partnerships with other HIV research disciplines and with laboratory / translational researchers
new to HIV who are interested in non-AIDS comorbidities. The VPC’s cutting edge tools for studying HIV at the
molecular, cell, tissue, and organismal levels include highly sophisticated instrumentation; experienced technical
support and customized training; and expert consultation / navigation for new technologies, creative
experimental designs and innovative pathogenic hypotheses. A primary objective of the VPC is to make these
approaches equally available to the molecular virologist, the clinical/translational researcher, and the
behavioral/social scientist. VPC adds value and the necessary rigor in all experimentation, including for projects
that previously had limited or no access to approaches such as multiplex biomarker assays and virologic
assessments. The Data Insight Group (DIG) is expanding consultation and navigation to specialized multi-omics
approaches to studies of this virus, as well. The DIG brings together an exciting group of young investigators
utilizing advanced technologies in their own research programs as a mechanism to extend incorporation of these
approaches into other TC CFAR members’ research. Customized mentorship, navigation and training w...

## Key facts

- **NIH application ID:** 9999259
- **Project number:** 2P30AI117943-06
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Thomas Hope
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $272,894
- **Award type:** 2
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9999259

## Citation

> US National Institutes of Health, RePORTER application 9999259, Viral Pathogenesis Core (2P30AI117943-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9999259. Licensed CC0.

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