Project Summary/Abstract The Developmental Research Program (DRP) is an integral part of the UCSF Brain Tumor SPORE and represents the best opportunity to explore new ideas as pilot projects, to develop new resources, to apply new technologies to translational brain tumor research, and to promote collaborations among scientists at UCSF and outside institutions. In this manner the DRP ultimately serves as a means to build and support new technologies, to support the early stage development of projects that can compete successfully for peer- reviewed funding, and, in the best case scenario, for inclusion as full projects in the SPORE Program. The Specific Aims of the UCSF Brain Tumor SPORE DRP are: 1. To implement new technologies and resources for translational brain tumor research 2. To help develop collaborations among scientists within UCSF and at different institutions 3. To develop new ideas as pilot projects to replace SPORE projects or generate other funding