# Data Management and Bioinformatics Core

> **NIH NIH U19** · SCRIPPS RESEARCH INSTITUTE, THE · 2020 · $330,758

## Abstract

Summary
The Data Management and Bioinformatics Core (DMBC) will support each of the Projects and the overall goals
of the program by applying multiple types of computational analyses to determine the functional role of novel
immune regulators. This work will include: (i) processing and performing bioinformatics analysis of the large-
scale data sets generated within the Projects and Cores; (ii) identifying genes, proteins, epigenetic
modifications and tissue phenotypes that are most affected by immune perturbations; and (iii) by integrating
internally generated and publicly available data sets to identify relevant co-expression modules and infer key
regulators underlying immune phenotypes. Fully exploiting high throughput technologies such as RNA-seq,
ChIP-seq and ATAC-seq, as well as multi-parameter molecular phenotyping (CyTOF, MIBI, CODEX) requires
significant infrastructure and sophisticated analysis methods. The DMBC has deep expertise in the analysis of
data generated by these technologies and has developed computational tools to discover novel immune
regulators and determine their mechanisms of action. Furthermore, the DMBC has necessary resources to
manage and analyze these large data sets and disseminate them to the program investigators and to the
public via websites and existing public databases.
The Core has developed a proven model for the informatics core in which individual computational
investigators are imbedded within each of the projects. The advantage of this structure is that the
computational biologists can participate at every level of the experimental program. The Core has found this
structure to be particularly effective given the broad range of approaches used disparate at the various centers
(systems biology, genetics, multi-parameter signaling analysis).

## Key facts

- **NIH application ID:** 9999447
- **Project number:** 5U19AI100627-09
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** ALAN A ADEREM
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $330,758
- **Award type:** 5
- **Project period:** 2012-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9999447

## Citation

> US National Institutes of Health, RePORTER application 9999447, Data Management and Bioinformatics Core (5U19AI100627-09). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9999447. Licensed CC0.

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