# Genetic Analysis of TLR Signaling and Innate Resistance to Viral Infection

> **NIH NIH U19** · SCRIPPS RESEARCH INSTITUTE, THE · 2020 · $550,038

## Abstract

Project Summary
We have developed and applied a highly automated system of random germline mutagenesis to probe TLR
signaling and resistance to viral infection in mice. The search for still more proteins involved in TLR signaling
will continue as we have not yet approached saturation of the genome. Moreover, we have identified a number
of genes with essential functions in these processes and propose to study them further. As new and essential
components of the system are identified we will seek to understand them mechanistically using tools of
biochemistry, cell biology, and genetics. We will also analyze the antagonistic relationship between MyD88 and
Ticam1 by placing specific markers of the inhibitory influence exercised by each adaptor protein under
surveillance. We envision close collaboration with our colleagues in Seattle, Stanford, La Jolla and Sydney, with
whom we have worked for many years.

## Key facts

- **NIH application ID:** 9999450
- **Project number:** 5U19AI100627-09
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** BRUCE A BEUTLER
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $550,038
- **Award type:** 5
- **Project period:** 2012-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9999450

## Citation

> US National Institutes of Health, RePORTER application 9999450, Genetic Analysis of TLR Signaling and Innate Resistance to Viral Infection (5U19AI100627-09). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9999450. Licensed CC0.

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