CAREER: Leveraging natural diversity to uncover the genetic basis of host-microbiome interactions

NSF Award Search · 01002526DB NSF RESEARCH & RELATED ACTIVIT · $1,370,418 · view on nsf.gov ↗

Abstract

The human gut microbiome is made up of trillions of microbes that influence digestion, immunity, and overall health. Scientists have found that people vary widely in the communities of microbes they host, but the reasons for this variation remain unclear. While studies suggest that genetics plays a role, it is not yet understood how specific genetic differences shape the microbiome. This project uses the Mexican tetra, a small fish with surface-dwelling and cave-dwelling forms, to explore how genes influence gut microbes. These fish have evolved in drastically different environments and display unique metabolic traits and microbiome profiles, even when raised under identical lab conditions. Their natural diversity makes them an ideal model for identifying the genes that shape gut microbes and for testing how those microbes affect traits like fat storage and blood sugar levels. In addition to advancing scientific knowledge, the project promotes STEM education and public engagement. A new course module for graduate students will provide training in modern genetic techniques. Undergraduate students will gain paid, hands-on laboratory research experience through a structured mentorship program. To support early science learning, the team will partner with the UNR Museum of Natural History to create an interactive lab activity for visiting elementary school groups using live fish. The museum will also host a public exhibit featuring the Mexican tetra to highlight how animals adapt

Key facts

NSF award ID
2439248
Awardee
Board of Regents, NSHE, obo University of Nevada, Reno (NV)
SAM.gov UEI
WLDGTNCFFJZ3
PI
Misty Riddle
Primary program
01002526DB NSF RESEARCH & RELATED ACTIVIT
All programs
UNDERGRADUATE EDUCATION, CAREER-Faculty Erly Career Dev, GRADUATE INVOLVEMENT
Estimated total
$1,370,418
Funds obligated
$1,101,668
Transaction type
Continuing Grant
Period
09/15/2025 → 08/31/2030