CAREER: Identical Brains in Two Zebrafish: Optical Programming and Replication of Brains

NSF Award Search · 01002526DB NSF RESEARCH & RELATED ACTIVIT · $600,000 · view on nsf.gov ↗

Abstract

The brain is composed of specific cells called neurons that connect to form circuits. These brain circuits allow the brain to process information, control bodily functions, and regulate behavior. However, these circuits can malfunction, which can lead to brain disorders. This research project aims to address challenges in damaged neuron circuits by "reprogramming" the brain. The long-term goal is to develop new ways to change and repair brain circuits, which will help understand how to treat brain disorders. The project will use zebrafish larvae as a model system to demonstrate that signals can be transferred from a healthy brain to a damaged one with the goal of rebuilding the malfunctioning circuits. The project will engage students and the public in science, technology, engineering, and math (STEM) activities. Local high school students will help build novel brain interfaces to demonstrate control over zebrafish movement. College students will create interfaces to demonstrate signal transfer between zebrafish and robots. These activities will be shared through educational videos and outreach events that will allow the community to learn more about neurons and brain. This research will improve our understanding of brain development and highlight the importance of early intervention for brain disorders. Within the brain, neurons interconnect to form neural circuits, which are essential for processing information, controlling bodily functions, and regulating behavior. Howe

Key facts

NSF award ID
2440448
Awardee
University of Illinois at Chicago (IL)
SAM.gov UEI
W8XEAJDKMXH3
PI
Eunjung Jung
Primary program
01002526DB NSF RESEARCH & RELATED ACTIVIT
All programs
CAREER-Faculty Erly Career Dev
Estimated total
$600,000
Funds obligated
$600,000
Transaction type
Standard Grant
Period
09/01/2025 → 08/31/2030