This REU Site award to the University of Washington, located in Seattle, WA, will support the training of ten students for nine weeks during the summers of 2025-2027. The rapid advances in genome engineering and sequencing technology have propelled biological research and its commercial applications forward. Genome-scale technologies have transformed medicine, agriculture, energy production, and information technology resulting in many job opportunities for students pursing technology development and computational biology. At the REU Site: Novel Genome-Scale Technologies and Big Data Science, undergraduate students will witness and experience research at the forefront of technology development in genomics and proteomics. This experience will uniquely prepare them for the competitive marketplace of ideas and provide skills that are applicable in a wide range of fields, including biology, computer science and engineering. Their newly acquired skills will benefit the much needed workforce development for the emerging bioeconomy. The students will learn how rigorous research is conducted, and many will present the results of their work at scientific conferences. Assessment of this program will be done through external tools (e.g., Qualtrics). Students should apply to the REU site using NSF ETAP (Education and Training Application: https://etap.nsf.gov). This nine-week program will introduce participating students to leading researchers in technology and algorithm development i